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Omega-3 fatty acid intake effect on allergy severity

Omega-3 fatty acid intake effect on allergy severity. MBA 555 Fall 2011 Rebecca Fan. Introduction. Epidemiological research has indicated that allergy disease is triggered by the combination of both genetic and environmental factors

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Omega-3 fatty acid intake effect on allergy severity

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  1. Omega-3 fatty acid intake effect on allergy severity MBA 555 Fall 2011 Rebecca Fan

  2. Introduction • Epidemiological research has indicated that allergy disease is triggered by the combination of both genetic and environmental factors • Few studies has reported that intake of omega-3 fatty acid could potentially reduce the blood pressure and allergy severity level • Omega-3 supplementation during pregnancy and lactation could decrease the risk of childhood asthma; however the evidence was not conclusive across different studies

  3. Introduction • Serum IgE level has been recognized as the surrogate for allergy severity level measurement • Variations of normal total serum IgE can range from 150 to 1,000 UI/ml; however the acceptable upper limit is usually between 150 and 300 UI/ml

  4. Objectives • Investigate the relationship between allergy severity level reduction and omega-3 intake • Understand how other factors such as age, gender, height, weight, smoking and prior history of allergy could impact the effect between omega-3 intake and serum IgE level • H0: Daily omega-3 intake(g/d) has a significant effect on serum IgE level(UI/ml), either positive or negative (two-sided test)

  5. Data source and study population • De-identified data from an allergy treatment clinical trial (on-going) • 46 individuals with complete demographic information collected including: age, height, weight, gender (1=male;2=female), smoking status (1=yes;0=no), and previous allergy history (1=yes;0=no)

  6. Analysis • Software tool: WinORS • Models - Ordinary Least Square (OLS) - Multiplicative model was applied to log transformed data in order to estimate the impact of % change in serum IgE level in responding to % change in omega-3 intake - Weighted Least Square (WLS)

  7. Result - OLS • White's Test for Homoscedasticity:P=0.14479

  8. Result - OLS • Normality test:P=0.987, Average VIF=1.491

  9. Result – Multiplicative Model • Elasticity parameter estimates:

  10. Result – WLS • Elasticity parameter estimates:

  11. Conclusion and implication • Elasticity of IgE level = 6.764+ (-0.76)*omega-3(g/d) + (-0.245)*SEX + (0.425)*PrevHis • Recommendation for nutrition intake: 10% increase in daily omega-3 intake could help to reduce serum IgE level by 8% • Gender variable suggested a protective effect for female (lower IgE level compare with same condition male), possibility because women in general are more health conscious than man

  12. References • Ann Med Interne (Paris). 1985;136(5):419-22. Laurent J et al. How to define the normal level of serum IgE in adults? • Acta Paediatr. 2009 Sep;98(9):1461-1467. Furchjelm C et al. Fish oil supplementation in pregnancy and lactation may decrease the risk of infant allergy. • BJOG 2011 Jul;118(8):916-25. doi: 10.1111/j.1471-0528.2010.02846.x. Klemens CM et al. The effect of perinatal omega-3 fatty acid supplementation on inflammatory markers and allergic diseases: a systematic review. • Fur M Med Res. 2009 Dec 7;14 Suppl 4:248-54.Wilczyska-Kwiatek A et al. Asthma, allergy, mood disorders, and nutrition. • Allergy. 2009 Jun;64(6):840-8. Epub 2009 Apr 7. Anandan C et al. Omega 3 and 6 oils for primary prevention of allergic disease: systematic review and meta-analysis.

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