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Isnu2019t there a pill I can take?u201d This is not an uncommon<br>question from patients with glaucoma. Often, it is posed<br>by those who are on a four-drop regimen and still experi-<br>encing progression, those who struggle with debilitating<br>ocular surface disease, or those who lack the dexterity<br>to instill drops reliably. Some systemic medications can<br>effectively lower IOP, however; because of side effects,<br>metabolic requirements, and potential toxicity, clinicians<br>do not prescribe them as freely as they do topical thera-<br>peutics. The two classes of systemic ocular antihypertensive<br>medication
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