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Preservatives

PRESENTATION ON. Preservatives. Preservatives. Preservatives are those chemicals which used alone or in combination to prevent the growth of microorganisms in solution. Example of preservatives:. Sodium benzoate Potassium sorbate Methyl hydroxybenzoate ( methylparaben )

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Preservatives

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  1. PRESENTATION ON Preservatives www.AssignmentPoint.com

  2. Preservatives • Preservatives are those chemicals which used alone or in combination to prevent the growth of microorganisms in solution. www.AssignmentPoint.com

  3. Example of preservatives: • Sodium benzoate • Potassium sorbate • Methyl hydroxybenzoate (methylparaben) • Benzoic acid • Chlorobutanol • Sorbic acid www.AssignmentPoint.com

  4. Properties of Preservatives • Be chemically and physically stable over the shelf-life of the product • Have low toxicity. • It should not be Adsorbed on to the container. • It should be compatible with other formulation additives. • Its efficacy should not be decreased by pH. www.AssignmentPoint.com

  5. Preservatives in solution: • Alcohols, acids, esters and quaternary ammonium compounds are some chemicals which used in solution as preservatives to prevent microbial contamination. • Example: • Alcohol. e.g. Ethanol(> 10%) • Acids. e.g. Benzoic acid(0.1 % to 0.5%) • Esters. e.g. Parabensup to about 0.2%. • Quaternary Ammonium Compounds. • e.g. Benzalkonium chloride(0.002 -0.02%). www.AssignmentPoint.com

  6. Preservatives in suspension • The naturally occurring suspending agents such as tragacanth, acacia, xanthan gum are susceptible to microbial contamination. If suspension is not preserved properly then the increase in microbial activity may cause stability problem such as loss in suspending activity of suspending agents, loss of color, flavor and odor etc. • Example: • Benzalkonium chloride ; (0.01-0.02) % • Disodium edentate ; 0.1 % • Propyleneglycol ; (5-10) % www.AssignmentPoint.com

  7. Perservatievs in Emulsion • Some preservatives are used in pharmaceutical emulsion to maintain products availability and activity. The antimicrobial activity varied with the type of preservative and microorganism. Appropriate preservatives are used in emulsion to prevent contamination such as: • Color and odor change • Gas production • Hydrolysis • pH change • Breaking of emulsion www.AssignmentPoint.com

  8. Side Effect of using Preservatives: • Preservatives have been linked to negative health outcomes in scientific literature. Preservatives can be transformed into harmful substances after consumption. For example, preservatives can become carcinogens. • But in pharmaceuticals, if we maintain the concentration of preservative then it does not give any side effect. www.AssignmentPoint.com

  9. Thank You All  www.AssignmentPoint.com

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