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Minimally Invasive Compressional Assist Device

Minimally Invasive Compressional Assist Device

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Minimally Invasive Compressional Assist Device

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  1. Minimally InvasiveCompressional Assist Device Erika Brown, Caryl Brzymialkiewicz, and Mark Carlson Advisor: Dr. Drew Gaffney, M.D. Professor of Medicine, VUMC

  2. Project Definition To design a cardiac assist device, implantable with minimally invasive surgery that aids in pumping, and in the case of a hypertrophic heart, also improves function over time.

  3. Cardiac Indications • Systolic Ejection Fraction • Stroke volume _ End Diastolic Volume • Hypertrophic heart (e.g. Chagas disease) • sarcomeres expand and lose contraction efficiency • self-perpetuating positive feedback system Frank-Starling Curve

  4. OPTIONS Extracorporeal assist devices Heart transplants Total Artificial Hearts Ventricular Assist Devices Batista’s wedge resectioning surgery Various drug treatments (ie - digitalis) PROBLEMS Invasiveness Cost Mortality Discomfort Length of use Aid in pumping or healing, but not both Recipient limitations What is currently available?

  5. Project Overview • Brainstorming until end of January • Research until mid-February • In vitro model design and testing through mid-March • Evaluation of in vitro results and adaptation into a prototype clinical design by end of the semester

  6. What have we done so far? • Web page is up and running • Patent search • Located pertinent cardiology and instrumentation resources • Began in depth review of current technologies • Brainstormed wants and needs, possible design options, potential problems

  7. What are we currently doing? • Continuing review of current technologies/devices • Biomaterials research • Re-evaluating our problem and looking for alternative solutions • Trying to set up viewing of cardiac surgery

  8. Current questions... • How much pressure should be applied to help the heart pump effectively? • What is the most effective triggering mechanism? • Quantitatively, how much pressure is needed over what length of time to help heal a hypertrophic heart? • What are the anatomical constraints in implanting a device sub-xyphoidally?

  9. What will we do next? • Make a evaluation matrix of potential solutions • Focus brainstorms on best solution and develop concepts for in vitro model • Specify design parameters • Develop tests for in vitro model • Research Batista’s wedge resection surgery

  10. Resources • Sherwood, L. (1997) Human Physiology: From Cells to Systems, 3rd Ed. Wadsworth Publishing Co.: Belmont, CA. • Quall, S.J., ed. (1993) Cardiac Mechanical Assistance Beyond Balloon Pumping. Mosby Year-Book, Inc.: St. Louis, MO.