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Diabetic Emergencies

Diabetic Emergencies . Andjela Drincic M.D. . Diabetic Emergencies. Case Presentation Pt is a 32yo female with a hx of type 1 DM who presents with a cc of N/V, and diffuse abdominal pain for 24 hours What other questions would you like to ask. Diabetic Emergencies. Case Presentation

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Diabetic Emergencies

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  1. Diabetic Emergencies Andjela Drincic M.D.

  2. Diabetic Emergencies • Case Presentation • Pt is a 32yo female with a hx of type 1 DM who presents with a cc of N/V, and diffuse abdominal pain for 24 hours • What other questions would you like to ask

  3. Diabetic Emergencies • Case Presentation • Pt denies F/C, URI symptoms, urinary symptoms except for frequency • Pt also states that she has been using her insulin correctly, but she had not taken any insulin for the last 24 hours because she wasn’t able to eat anything

  4. Diabetic Emergencies • Case Presentation • PMHx: Diagnosed with DM after episode of DKA approx 7 years ago. • Meds: Insulin 70/30 28UqAM, 16UqPM • NKMA • SHx: Single, no children, (+) Tob 1ppd for 12 years, occ EtOH use, no recreational drugs • FHx: (+) HTN • What are pertinent findings on physical exam?

  5. Diabetic Emergencies • Physical Exam • Gen: Mild distress but A&O x 3 • 97.4, 120, 34, 132/88 • HEENT: WNL • Heart: RR Lungs: CTA-B • Abd: (+) BS, diffuse tenderness, no rebound • Ext: WNL Neuro: WNL • What Lab Data would you like to obtain?

  6. Diabetic Emergencies • Case Presentation • Lab Data • WBC 15.7, H/H 15/45 Plt 229 • NA 132, K 5.2, CL 96, HCO 11, BUN 10, Cr 1.0 Glucose 612, Ca 12.1, Phos 6.6, Mg 2.1

  7. Diabetic Emergencies • Case Presentation • Lab Data Analysis • NA 132, K 5.2, CL 96, HCO 11, BUN 10, Cr 1.0 Glucose 612, Ca 12.1, Phos 6.6, Mg 2.1 • What is the anion gap? • What is the actual serum sodium? • What is the differential diagnosis for wide anion gap metabolic acidosis?

  8. Formulas you may need • sOsm = 2 (Na + K ) + Glu/18 + BUN/2.8 + ETOH/4.6 • AG = Na - ( Cl + HCO3) • Na = Na + 1.6 x (Glu - 100)/100

  9. Diabetic Emergencies • Case Presentation • Lab Data (Continued) • UA: Protein 3+, Large ketones • Serum ketones were 1:16 • Serum osmolarity was 323mOsm/kg

  10. Diabetic Ketoacidosis (DKA) • Life-threatening emergency • Gross insulin deficiency is the predominant problem of DKA • Most common in patients with type 1 diabetes • Can occur in patients with type 2 diabetes due to progressive loss of β-cell reserve • Mortality is ~5%–10% Fishsbein H, Palumbo PJ. Acute metabolic complications in diabetes. In: National Diabetes Data Group. Diabetes in America. Bethesda (MD): National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases: 1995:283-291.

  11. Symptoms Blurred vision Increased thirst Increased urination Nausea/vomiting Confusion Loss of consciousness Signs Deep respirations Fruity breath Dehydration Hyperglycemia Ketosis Acidosis Treatment Give insulin in a sufficient amount Attention to the potassium level is also important Hydration Signs, Symptoms, and Treatment of Diabetic Ketoacidosis

  12. Type 1 DMhormonal pathophysiology - Insuln deficiency: decreased glucose utilization - Elevations in counterregulatory hormones: increased lipolysis in adipose tissue increased proteolysis in muscle increased glycogenolysis increased gluconeogenesis hepatic ketogenesis Leading to DKA

  13. Hyperosmolar Hyperglycemic State (HHS) Life-threatening emergency • Occurs in patients with type 2 diabetes • Characterized by very high blood glucose levels without ketones • insulin secretion is maintained to prevent peripheral lipolysis , liver able to metabolize FFA in a nonketogenic manner • relative insulin deficiency : decreased peripheral uptake and increased hepatic gluconeogenesis • hyperglycemia, hyperosmolality • osmotic diuresis and volume and electrolyte depletion

  14. DKA/HHS • not mutually exclusive ! • Criteria for DKA • hyperglycemia ( glu>250 mg/dl) • ketosis • acidemia ( pH <7.3)

  15. Pathophysiology of DKA/HHS Insulin Deficiency Increased Lipolysis Hyperglycemia Increased ketogenesis Osmotic Diuresis Ketoacidosis Hyperosmolality Pure Diabetic Ketoacidosis Pure Hyperosmolar State

  16. DKA • Absolute insulin deficiency and counter-regulatory hormones promote lipolysis • shift in hepatic lipid metabolism of incoming fatty acids due to high ratio of glucagon to insulin in portal flow - fall in malonyl co A levels and disinhibition of CPT • CPT catalizes beta oxidative pathway- fatty acids are oxidized to form ketone bodies rather than re-esterified into TG

  17. Physiology of DKA Insulin glucagon Triglyceride Free Fatty Acids Free Fatty Acids Free Fatty Acids Fatty Acyl Co A Acetyl Co A HMA Co A Acetoaceteate Hormone Sensitive Lipase Adipocyte Serum Glucagon Malonyl Co A Hepatocyte Carnitine palmitoyl transferase 1 Mitochondria 3 hydroxybutyrate Acetone

  18. history of DM , medications and symptoms history of complications utilization of medications social history ( including alcohol) vomiting precipitating factor - pregnancy, infection, omission of insulin, MI, CVA asses hemodynamic status examine for infection Evaluation of patient

  19. BMP CBC serum ketones calculate serum osmolality and AG measure serum osmolality if ingestion of osmotically active substance other than glucose suspected UA and culture consider blood culture CXR consider HCG ABG if indicated clinically HbA1c Laboratory Evaluation

  20. “Euglycemic ketoacidosis “ • Glu < 300 mg/dl • HCO3 < 10 mEq/l • Usually in pump pts ( no “back-up insulin)

  21. Other expected labs in DKA • Hyponatermia unless pt is dehydrated • Hyperkalemia due to cellular shift • Leukocytosis in the absonce of infection • Elevation of amylase and lipase in the absence of pancreatitis

  22. “Serum Ketone Negative DKA” • Alcoholic ketoacidosis • Hypoxia • Beta hydroxybutirate is the dominant ketone • Not detected by nitroprusside reaction

  23. addapted from Joslin’s Diabetes Mellitus 14th edtion , 2005 Gudelines ofr therpay of DKA/HHS

  24. Suggested Fluid Replacement in DKA/HHS • Administer NS as indicated to maintain hemodynamic status than follow general guidelines: • NS for first 4 hours • consider 1/2 NS thereafter • Change to D5 1/2 NS when BG < 259 mg/dl • may need to adjust type and rate of fluid administration in the elderly and in patients with CHF and CRF

  25. Suggested fluid replacement in DKA /HHS • 1st hour : 1 l • 2nd hour : 1 l • 3rd hour : 500 ml - 1 l • 4th hour: 500 ml - 1 l • 5th hour : 500 ml - 1 l • Total 1st - 5th hour 3.5 - 5 l • 6th - 12th hour : 250 - 500 ml/hr

  26. Guidelines for Insulin Management in DKA/ HHS • regular insulin 10U I.v. stat ( for adults) or 0.15 U/kg I.v. stat • start regular insulin infusion 0.1 u /kg per hour or 5 U per hour • Increase insulin by 1 U per hour every 1-2 hours if less than 10 % decrease in glucose or no improvement in acid - base status • decrease insulin by 1-2 U/hr when BG < 250 mg/dl and/or progressive improvement in clinical status with decrease in glucose >75 mg/dl /hr • do not decrease insulin infusion to < 1 u /hr • maintain BG 140 - 180 mg/dl • if BG < 80 mg/dl , stop insulin infusion for no more than 1 hour and restart the infusion • if BG drops consistently to <100 mg/dl , change I.V. fluids to D 10 to maintain BG 140 - 180 mg/dl

  27. Insulin Infusion Algorithm • 1. Discontinue all subcutaneous insulin use • 2. Measure blood glucose every hour • measure urine ketones after each void every 4 hours • 3. Give D5%W iv via insulin infusion pump • 4. Make insulin solution using regular insulin to a concentration of 0.5 U/ml

  28. Insulin Infusion AlgorithmNewton et al:Arch Intern Med 164,sept 27, 2004

  29. Guidelines for K replacement in DKA/HHS • Do not administer K if serum K > 5.5 mEq/l or if patient is anuric • Use KCl but alternate with KPO4 if there is severe phosphorus depletion and patient is unable to take phosphorus by mouth • Add I.V. KCl to each liter of fluid administered unless contraindicated

  30. Guidelines for K replacement in DKA/HHS • serum K ( mEq/L) Additional K required • <3.5 40 mEq/L • 3.5 - 4.5 20 mEq/L • 4.5 - 5.5 10 mEq/L • > 5.5 Stop K infusion

  31. Guidelines for Bicarbonate Therapy in DKA • PRO: severe acidosis is associated with adverese effects:hypotension, decreased cardiac output decreased peripheral vascular resistance, increased pulmonary arterterial resistance , bardycardia, arrhytimas , renal and mesenteric ischemia, cerebral vasodilatation • CONS: no studies have shown any benefit of bicarbonate if pH is 6.9-7.1 • SIDE EFF : overshoot alkalosis, paradoxical CSF acidosis , hypokalemia, volume overload, overproduction of ketoacids

  32. Guidelines for Bicarbonate Therapy in DKA • Use clinical judgement in deciding if bicarbonate therapy is indicated • if pH is < 7.0 consider 100 ml HCO3 over 45 min • ( mix 100 ml NaHCO3 with 400 ml sterile water and administer at rate of 200 ml/hr) • check ABG 30 min later

  33. Phosphate replacement • Phos depletion is common: renal loss, intracellular uptake during insulin Rx • problem: low cardiac output, respiratory muscle weakness, rhabdomyolisis , CNS deppression , seizures , coma, renal failure • CAVE : iv Phos leads to hypocalcemia • no benefit in routine replacement • reserve replacement Rx if phos < 1.5 mg/dl AND in whom Ca is normal • use of small amount of Kphos and KCL iv is safe and effective • but oral replacement preferred to I.V.

  34. Monitoring of RX • BG hourly • electrolytes and acid base status every 2-4 hours • ok to check venous pH if you can’t get art line ( 0.03 unit less than arterial ) • frequent measurement of ketones may be misleading (  hydroxybutirate is converted to acetoacetate) • consider using bedside measurement of ß hydroxybutirate • repeat CXR after 4 l fluids administered

  35. Complications of RX • hypoglycemia • hypokalemia • hypophosphatemia • hyperchloremia and hyperchloremic acidosis - chloride losses are less severe than sodium losses but replacement solutions have equal par tof Na and Cl • hypoalcemia • cerebral edema - children • DVT/PE ( dehydration as a risk factor)

  36. DKA - is it always type 1 DM? • Arch Int Med 1999 159:2317 - • epidemiology of pts admitted for DKA : type 1 DM in • 80 % of whites • 53% of African Americans • 34 % of Hispanics • no difference in electrolytes,glu, pH, AG, pOsm or level of ketosis • majority of pts with type 2 , no preciptating event !

  37. A” Real Life “ case • 55 y/o AAF • no previous h/o DM • comes with polyuria,, polydipsia, fatigue • Vitals: 96.9, 130, 24, 122/63 • Labs: WBC 19, BS 502, K 6.0, Na 128, CO2 5

  38. Orders • Dx DKA • IVF NS 3l bolus than 200 cc/hour • 2 amps HCO3 • blood cultures, sputum cultures,accucheck q 1hour • diabetic education in am • cbc , bmp in am • bmp q 2hours x 4, UA • Mg, PO4 levels

  39. Insulin gtt: U/hour • 0-50 off • 70 - 100 0.3 • 101- 129 0.4 • 130 - 170 0.5 • 171 - 200 0.6 • 201 -230 0.8 • 231 - 270 1.0 • 271 - 300 2.0 • 300 - 330 4.0 • >330 4.0

  40. Orders - cont • 4 hours later - K 3.0 , BS 347 • order : 40 mEq KCl now • change IVF to D5 NS with 40 KCl at 200 cc/hour • 6 hours later: phos 1.2 • order : 40 mEq K phos IV • soft diet for pt • 24 hours later , BS 350

  41. Diabetic Emergencies • Hypoglycemia • Whipple Triad • Consistent signs and symptoms • Low blood glucose • Relief with supplemental glucose • Two categories of hypoglycemia • Reactive • Nonreactive

  42. Diabetic Emergencies • Hypoglycemia • Reactive Hypoglycemia • Develops in response to a nutrient challenge • Seen in pts with type 2 DM (???) and post GI surgery pts • Idiopathic form • Nonreactive Hypoglycemia • Iatrogenic • Fasting/Factious

  43. Diabetic Emergencies • Hypoglycemia • Fasting/Factious Hypoglycemia • 3 main causes • Factitious taking of oral hypoglycemics/insulin • Autoimmune etiology • Insulinoma from an islet cell tumor • Heavy EtOH can also cause hypoglycemia • Three tests for workup of nonreactive hypoglycemia • Serum insulin • C-peptide • Urinary sulfonylurea test

  44. Diabetic Emergencies • Hypoglycemia • C-peptide • Elevated indicates endogenous insulin secretion and is low if there is factitious insulin injection • High levels seen in autoimmune hypoglycemia, insulinoma, and sulfonylurea ingestion • Urinary sulfonylurea test will rule in or out oral hypoglycemic use • Insulin levels • < 100 suggest insulinoma • > 100 suggest autoimmune

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