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Understanding Notch Signaling and Its Role in Cell Differentiation and Mutation Effects

This correspondence explores the complex mechanisms of Notch signaling in progenitor cell differentiation, particularly how cells expressing Notch receptors develop into neuronal cells, while those expressing Numb remain as stem cells. Additionally, questions arise about the clarity of Notch dimers and their implications. Furthermore, there is an inquiry into the effects of mutations and ATG changes on the growth of HMGA2, emphasizing the significance of these biological processes in cellular development and growth regulation.

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Understanding Notch Signaling and Its Role in Cell Differentiation and Mutation Effects

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  1. Hi Professor Scheid, From a dividing progenitor cell, cells that express Notch receptor become neuronal cells and cells that express Numb and inhibit Notch stay as stem cell? Or is the other way around? Regards, Hey Professor Scheid, I don’t get that notch dimer thing. Can you expalin again pls. thx . Thanks, Hi Dr. Scheid, How do the mutation and ATG change HMGA2 growth? Best,

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