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2011 년 2 분기 정리

2011 년 2 분기 정리. 화순전남대학교병원 미토콘드리아 연구실 ( Molecular Diagnostics and       Mitochondrial Research Laboratory ). http://www.mtdna.or.kr. http://www.haenamskin.com. 2011. 07. 20 ( 수 ). Molecular Diagnostics and Mitochondrial research laboratory. Treatment Outcome.

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2011 년 2 분기 정리

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  1. 2011년 2분기 정리 화순전남대학교병원 미토콘드리아 연구실 (Molecular Diagnostics and       Mitochondrial Research Laboratory) http://www.mtdna.or.kr http://www.haenamskin.com 2011. 07. 20 (수)

  2. Molecular Diagnostics and Mitochondrial research laboratory Treatment Outcome Hematopoietic Stem cells Hematopoietic Ds MRD determination Biomarkers Chronic Degenerative Diseases Potential new therapeutics New molecular Pathophysiology Cancer/Aging Diagnosis

  3. 정리 내용 • 연구원 동정 • 학술대회 참가 및 초록발표 • Accepted manuscript • 준비중인 SCI논문 • 연구과제 수행

  4. 2011년 MTDNA연구팀연구원 동정 현재 신명근 교수님, 김혜란, 김환영 연구원 • 2011.01.19 미토콘드리아 실험실 홈페이지 구축 (www.mtdna.or.kr) • 2011.02.05 김환영 연구원 광주보건대학 전공심화과정 졸업 • 2011. 02.25 안애자, 엄하영 선생님 석사 졸업 • 2011.03.01 김혜란 박사님 BK 의생명 인력사업단 Post-Doc 3년차 재계약 • 2011.03.05 김민영 연구원 광주보건대학 전공심화과정 입학 • 2011.04.11 미토콘드리아 실험실 2011년 1분기 모임 • 2011.06.03 2011소아암환경보건센터 세미나 개최 (경희대 의대 김원교수님) • 2011.06.11-12 화순전남대병원 소아암환경보건센터 심포지움 (변산대명리조트) • 2011.06.20 김민영 연구원 한국병원 입사

  5. 2011 학술대회 참가 및 초록제출 1) Korea-Germany International Joint Symposium- 2011.03.04 화순전남대 병원 대강당 ‘Molecular diagnostics and mitochondrial research in cancer and chronic inflammatory diseases’ 2) 미토콘드리아허브제어연구센터 초청강의 - 2011.03.24 부산 동아의대 ‘Translational Mitochondrial Research in Hematopoietic and Chronic Inflammatory Diseases’ 3) 2011 ISLH, New Orleans, Louisiana (2011.5.6-8) - Mitochondrial DNA copy number and hnRNP A2/B1 protein are biomarkers for benzene itself-related toxicity and hematotoxicity - Metformin selectively kills the AML stem cells through increased phosphorylation of AMP-activated protein kinase - The spectrum of mitochondrial genome instability in acute myeloid leukemia and leukemia stem cells 4) 2011 IGCC, 서울 코엑스 (2011. 4.20-23) - Mitochondrial genome instability in barrett's esophagus associated with increased production of reactive oxygen species

  6. 5) The 52nd Spring Meeting of the Korean Society of Hematology– 서울 그랜드힐튼호텔(2011.5.27-28) - Mitochondrial DNA Minisatellites Markers in Determination of Chimerism after Allogeneic SCT - Mitochondrial Genome Instability is Frequently Occurred in Acute Myeloid Leukemia Stem Cells (우수 연제상 수상) - Serum Fibrin Degradation Product is a Useful Biomarker for Diagnosis and Disease Monitoring in Multiple Myeloma - Dose Serum Free Light Chain Ratio Predict Prognosis for Newly Diagnosed Multiple Myeloma? - Increased Mitochondrial Mass and Mitochondrial DNA Copies are Biomarkers for Benzopyrene Exposure in Blood Cells and Hematopoietic Tissues - Effects of Storage Temperature, Type of Anticoagulant and Cryopreservation on Human Peripheral Blood Mononuclear Cells for the Assessment of NK Cell Cytotoxicity

  7. 6) 2011 Siemens Customer Seminar – 2011.06.15 광주 라마다 프라자 호텔 ‘Update Reciew, Clinicopathological Utility and Experience of Serum Her-2/neu Measurement’ 7) 융복합기술기반 신속통합진단 시스템 심포지엄 – 2011.06.22 화순전남대병원 대강당 ‘융복합 관점에서 신속진단검사 시스템 개발 필요성’ 8) Abbott Scientific Symposium- 2011.07.12 광주 라마다 프라자 호텔 ‘ProGRP is sensitive and specific tumor markers for small cell lung cancer’ 9) 유전 및 분자진단연구회 2011년 학술대회 - 2011.07.15 ‘Distinctive hematological abnormalities in East Asian neonates and children with down syndrome’ 포스터발표

  8. 2011 ACCEPTED MANUSCRIPT 1) Plasma proGRP concentration is sensitive and specific for discriminating small cell lung cancer from nonmalignant conditions or non-small cell lung cancer. (주저자/교신저자) J Korean Med Sci. 2011 May;26(5):625-30. Epub 2011 Apr 21. 2) Spectra of chromosomal aberrations in 325 leukemia patients and implications for the development of new molecular detection systems. (교신저자) J Korean Med Sci. 2011 Jul;26(7):886-92. 3) Distinctive hematological abnormalities in East Asian neonates and children with down syndrome. (주저자/교신저자) Int J Lab Hematol. 2011 Aug;33(4):369-377. 4) Genetic relationship of fluconazole non-susceptible Candida glabrata isolates from nine Korean hospitals. (공저자) Mycoses. 2011 May 23. [Epub ahead of print]

  9. 5) Genetic Diversity among Korean Candida albicans Bloodstream Isolates: Assessment by Multilocus Sequence Typing and Restriction Endonuclease Analysis of Genomic DNA by Use of BssHII.(공저자) J Clin Microbiol. 2011 Jul;49(7):2572-7. Epub 2011 May 11. 6) Multilocus Sequence Typing for Candida albicans Isolates from Candidemic Patients: Comparison with Southern Blot Hybridization and Pulsed-field Gel Electrophoresis Analysis. (공저자) Korean J Lab Med. 2011 Apr;31(2):107-14 7) Donor cell origin of multiple myeloma occurring after allogeneic haematopoietic stem cell transplantation in a patient with refractory anaemia with ring sideroblast. (주저자/교신저자) J Clin Pathol. 2011 Mar;64(3):265-8 8) 8p11 myeloproliferative syndrome with BCR-FGFR1 rearrangement presenting with T-lymphoblastic lymphoma and bone marrow stromal cell proliferation: A case report and review of the literature. (공저자) Leuk Res. 2011 May;35(5):e30-4.

  10. 9) Engineering and Visualization of Bacteria for Targeting Infarcted Myocardium. (공저자) Leuk Res. 2011 May;35(5):e30-4. 10) Genome-wide high density single-nucleotide polymorphism array-based karyotyping improves detection of clonal aberrations including der(9) deletion, but does not predict treatment outcomes after imatinib therapy in chronic myeloid leukemia. (공저자) Ann Hematol. 2011 Mar 8. [Epub ahead of print] 11) Treatment outcome of all-trans retinoic acid/anthracycline combination chemotherapy and the prognostic impact of FLT3/ITD mutation in acute promyelocytic leukemia patients. (공저자) Korean J Hematol. 2011 Mar;46(1):24-30 12) Biofilm formation and genotyping of Candida haemulonii, Candida pseudohaemulonii, and a proposed new species (Candida auris) isolates from Korea. (공저자) Med Mycol. 2011 Jan;49(1):98-102

  11. 2011 SUBMITTED MANUSCRIPT, UNDER REVIEW • Mitochondrial DNA copy number and hnRNP A2/B1 protein are biomarkers for direct exposure of benzene itself Environmental toxicology and chemistry(under review) • Alteration of Mitochondrial Genome and its Pathophysiologial Role in Barrett’s Esophagus Clinical Chemistry (under review)

  12. 2011 Manuscript preparation • Association of allelic expression imbalance of JAK2 V617F mutation and phenotypic diversity in MPN: • 김혜란/신명근 • 2) Prohibitin as a new biomarkers of leukemia for diagnosis, predicting prognosis, MRD monitoring and • molecular therapeutics: 김혜란/신명근 • 3) The spectrum of mitochondrial genome instability in acute myeloid leukemia and leukemia stem cells: • 김혜란/ 김환영/안애자/신명근 • 4) mtDNA instability in colon cancer: 김혜란/임상우/김환영/신명근 • Metformin selectively suppressed the proliferation of AML stem cells through increased phosphorylation • of AMP-activated protein kinase : 김혜란/ 엄하영/신명근 • 6) Serum fibrin degradation product is a valuable tumor marker for multiple myeloma: 김혜란/ 최현정/신명근 • 7) Mitochondrial minisatellite alterations in single AML stem cells associated with vicious cycle • hypothesis : 김혜란/ 김민영/김환영/신명근 • 8) Accuracy improvement for glucometer by reducing the hematocrit dependency using informatics • technology

  13. 2011 연구과제 수행 • 환경성 질환연구센터 3세부과제 • 한국연구재단 중견연구자사업 • 한국연구재단 해외우수연구소유치사업 2011 연구과제 프로포셜 • 보건산업진흥원 차세대유전체사업(센터사업)

  14. 소아암 환경보건센터 심포지움 Wheresoever you go, go with all your heart. 어디를 가든지 마음을 다해 가라. 감사합니다~

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