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PATHOLOGY PRACTICALS-II LEUKEMIAS & MULTIPLE MYELOMA

Learn about different types of leukemias, including Myeloblasts and Lymphoblasts, as well as Chronic Myeloid and Lymphoid Leukemia. Also, explore Multiple Myeloma and its characteristics in the bone marrow.

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PATHOLOGY PRACTICALS-II LEUKEMIAS & MULTIPLE MYELOMA

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  1. PATHOLOGY PRACTICALS-IILEUKEMIAS&MULTIPLE MYELOMA

  2. MYELOBLAST • 10-18 um diameter • Round to oval nucleus • 2-5 nucleoli in the nucleus • Chromatin in dispersed • Basophilic cytoplasm at time vacuolated • Auer rods seen in the cytoplasm • MPO POSITIVE • CD13, CD14, CD15 and CD33 antigen POSITIVE

  3. NORMOBLASTS MYELOBLAST

  4. Myeloblasts in AML Myeloblasts with Auer rods

  5. MYELOBLAST WITH AUER ROD

  6. LYMPHOBLAST • 10-18 um • Cytoplasm is agranular • Cytoplasm is moderately basophilic • Chromatin is coarse • 1-2 nucleoli • MPO NEGATVE • CD10.CD19,CD20 and CD22 antigen positive

  7. MYELOBLASTS LYMPHOBLASTS

  8. CHRONIC MYELOID LEUKEMIA Peripheral blood film shows- • Segmented neutrophils • Myelocytes, few myeloblasts (<10%) • Basophilia • Eosinophilia (Bimodal population of myeloid series of cells)

  9. CML- peripheral blood smear show immature myeloid cells, band forms and segmented mature neutrophils

  10. CML- peripheral blood smear shows myelocyte metamyelocyte, basophil and eosinophils

  11. CHRONIC LYMPHOID LEUKEMIA Peripheral blood film shows- • Absolute lymphocytosis (mature lymphocytes) upto 90% • Smudge cells/ smear cells

  12. CLL

  13. MATURE LYMPHOCYTES Markedly elevated in peripheral blood smear in CLL

  14. HAIRY CELL LEUKEMIA Peripheral blood film shows- • Abnormal mononuclear cells with hairy projections from the cell membrane

  15. HAIRY CELL LEUKEMIA • Malignant cells are positive for TRAP (tartrate resistant acid phophatase)

  16. HAIRY CELL LEUKAEMIA HAIRY CELLTRAP TEST +VE

  17. Reed Sternberg cell • Bilobed nuclei/owl-eyed nuclei with prominent inclusion like eosinophilic nucleoli. • Abundant blue cytoplasm • Surrounded by lymphocytes • Seen in Hodgkin lymphoma • CD 15 and CD 30 positive. • Variants- lacunar histiocyte, popcorn cell

  18. Burkitt’s lymphoma • 7 yearAfrican child with swelling of jaw • Tumor is ulcerated and draining Burkitt’s lymphoma Monotonous population of malignant lymphoid cells. Starry-sky pattern is due to tingle body laden macrophages (*) (containing the apoptotic tumor cell) * *

  19. MULTIPLE MYELOMA The bone marrow shows: • Plasma cells with basophilic cytoplasm, eccentric nucleus and coarse nuclear chromatin

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