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Agenda : Update master tracers Update validation vs pathology

X PMT meeting – June 6, 2012. Agenda : Update master tracers Update validation vs pathology Hippocampal 3D Object for AR Visualization Papers Next c ongress presentations & meetings. Benchmark Images. ADNI scans: 2 x 5 Scheltens’s atrophy score x 2 sides x 2 magnet strengths (1.5-3T)

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Agenda : Update master tracers Update validation vs pathology

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  1. X PMT meeting – June 6, 2012 • Agenda: • Update master tracers • Update validation vs pathology • Hippocampal 3D Object for AR Visualization • Papers • Next congress presentations & meetings

  2. Benchmark Images ADNI scans: 2 x 5 Scheltens’s atrophy score x 2 sides x 2 magnet strengths (1.5-3T) Total per rater: 40 hippos The 5 Master Tracers completed segmentation of R and L hippos of the 10 subjects received feedback in cases of little compliance to the Harmonized Protocol corrected segmentations accordingly

  3. Benchmark Images

  4. Validation vs Pathology

  5. Validation versus pathology 1 tracer? (which one? A master? A naive qualified on harmo prot?? O 3? (meglio 1…) ? ? how many Mayo Clinic AD + CTRL dataset with pathologically confirmed diagnosis (Braak’s stages), but not postmortem hippocampal measurement Mony DeLeon 15 AD + 5 CTRL at 1.5T postmortem MRI and quantitative histology (possible additional AD cases) Liana Apostolova (23 hippos at 7T) CA1 neuronal counts, tau and Abeta immunoreactivity measures ? Segmentation based on Harmonized Protocol: Tot ante mortem Tot 43 postmortem MRIs TOT images…… ? Analysis based on the information available for each dataset

  6. Validation versus pathology Originally designated sample: (Bobinski et al., 2000) 11 AD + 4 CTRL postmortem MRI and quantitative histology de Leon: 15 AD + 5 CTRL postmortem MRI and quantitative histology possible additional AD cases Jack: AD + CTRL dataset with pathologically confirmed diagnosis (controls and AD), but not post-mortem hippocampal measurement. Liana? 23 (one side only) 7T 60-hour postmortem scans (in progress: CA1 neuronal counts, tau and Abeta immunoreactivity measures)

  7. Hippocampal 3D Object for AR Visualization Segmentation Procedures Manual Tracing (Simon) Tool N° 1 (FSL-FIRST) Tool N° 2 (FreeSurfer) … … CTR SUBJ MODELs to be Compared through SPHARM vs. … Affected SUBJ CTR Aff Subj * * * … *MODELs in AR * Common in all Manual Tool1 Alg1 Alg2 Alg3 Alg n Tool2

  8. TOOL 1 Vs Manual Tracers TOOL 2 Vs Manual Tracers TOOL 3 Vs Manual Tracers

  9. Papers describing the project Survey of protocols (preliminary phase; published, JAD 2011) Operationalization (preliminary phase; I revision, Alzheimer’s & Dementia, MS n. ADJ-D-12-00094) Axes check short report (Brescia Team, in progress) Delphi consensus (Brescia Team, in progress) Master tracers’ practice and reliability (Brescia Team, in progress) Development of certification platform (Duchesne and coll) Validation data and Protocol definition (Brescia Team) Validation vs pathology (TBD)

  10. GOLDSTANDARD VALIDATION VS CURRENT PROTOCOLS ASSESSMENT OF SOURCES OF VARIANCE TRAINING SET DEVELOPMENT VALIDATION VS PATHOLOGY 20 naïve tracers 5 master tracers 1 tracer Local Protocol ADNI scans: 2 x 5 Scheltens’s atrophy scores x 2 sides x 2 magnet strengths (1.5-3T) Training ADNI scans: 10 at 1.5T x 2 sides x 7 SUs x 2 tracing rounds Total per rater: 40 hippos QUALIFICATION QUALIFICATION Harmonized Protocol ADNI scans: 2 x 5 Scheltens’s atrophy score x 2 sides x 2 magnet strengths (1.5-3T) Total per rater: 40 hippos Harmonized Protocol ADNI scans: 2 x 5 Scheltens’s atrophy score x 2 sides x 2 magnet strength (1.5-3T) Total per rater: 40 hippos Harmonized Protocol: Pathological datasets: Mayo Clinic and NYU Total: about 40 hippos Assessment of variance due to rater and center REFERENCE PROBABILISTIC MASKS with 95% C.I. Best 5 naïve tracers Assessment of agreement with volume on pathology or ex vivo MRI and correlation with neuronal density Harmonized Protocol ADNI scans: 2 sides x 5 Scheltens’s atrophy scores x 3 time points (bl-1y-2y) x 3 scanners (+ retracing @ bl) x 2 magnet strengths (1.5-3T) Total per rater: 240 hippos Assessment of variance due to side, trace-retrace, atrophy, time, scanner, rater TRAINING SET

  11. Next congress presentations - AIC 2012, Vancouver Abstract n. 26292, poster presentation Definition of Harmonized Protocol for Hippocampal Segmentation Session Date and Time: Saturday, July 14, 2012 - AAIC 2012, Vancouver Abstract n. 26291, oral presentation Definition of Harmonized Protocol for Hippocampal Segmentation Session Title: Neuroimaging 4: MCI: imaging markers of AD pathology Presentation Number: O2-11-02 Session Start Day Time: Jul 16 2012 3:30PM

  12. VI Hippocampal Protocol Harmonization Meeting AAIC – July 2012 Location: Fairmont Waterfront Vancouver, Princess Louisa Room Date & Time: Wednesday, July 18, 2012 at 1:00 PM - 2:30 PM AGENDA: Benchmark Images Qualification Platform Improvement of the Harmonized Protocol (based on the benchmark tracing phase) Validation Phase 2 Advancing Paper Publication Publication Policy

  13. GANTT

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