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Talk 3

Talk 3. Antibody. Structures of Five Classes of Igs. Species Horse Cattle Sheep Pig Dog Cat Chicken Mouse Human. IgG Ga, Gb, Gc, G(B), G(T)a, G(T)b G1, G2(G2a,G2b) G1(G1a?), G2, G3 G1, G2a, G2b, G3, G4 G1, G2, G3, G4 G1, G2, G3, (G4?) G1, (G2a?), (G3?) G1, G2a, G2b, G3

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Talk 3

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  1. Talk 3 Antibody

  2. Structures of Five Classes of Igs

  3. Species Horse Cattle Sheep Pig Dog Cat Chicken Mouse Human IgG Ga, Gb, Gc, G(B), G(T)a, G(T)b G1, G2(G2a,G2b) G1(G1a?), G2, G3 G1, G2a, G2b, G3, G4 G1, G2, G3, G4 G1, G2, G3, (G4?) G1, (G2a?), (G3?) G1, G2a, G2b, G3 G1, G2, G3, G4 IgA A A A1, A2 A1, A2 A A1, A2 A A1, A2 A1, A2 IgM M M M M M M M M M IgE E E E E E1,E2 E E E E IgD ? - - - D ? ? D D Classes and Subclasses of Igs from Human and Animals

  4. Antibody Structure

  5. Polymeric Structure of Antibodies

  6. Isotypes of Immunoglobulins IgG IgA The genes for isotypic variants are present in all healthy members of a species. For examples, the genes forγ1, γ2,γ3,γ4, , α1,α2,δ, ,  and  chains are all present in the human genome and therefore isotypes.

  7. Allotypes of Immunoglobulins IgG IgG Genetic variation between individuals within a species, involving different alleles at a given locus. Allotypes occur mostly as variants of H chain C region.

  8. Idiotypes of Immunoglobulins IgG IgG Variation in the variable domain, particularly in the hypervariable regions, produces idiotypes, which determine the binding specificity of the antigen-binding site. Idiotypes are usually specific for individual B-cell clone (private idiotypes ), but are sometimes shared between different B-cell clones (public, cross-reacting or recurrent idiotypes)

  9. Properties of Human Igs

  10. Functions of Antibody(Direct Neutralization)

  11. Functions of Antibody(opsonization)

  12. Functions of Antibody(ADCC Killing)

  13. Functions of Antibody(complement activation)

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