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+VE. BLOOD CULTURE (BC) RESULT. -VE. Clinical signs of infection?. Other pathogen?. Common skin organism?. 2 nd BC not performed. 2 nd BC - ve. 2 nd BC + ve. Y. N. Antibiotics already started?. Antibiotics given pre-BC?. Y. CVC in situ within 48 hours?. CVC in situ
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+VE BLOOD CULTURE (BC) RESULT -VE Clinical signs of infection? Other pathogen? Common skin organism? 2nd BC not performed 2ndBC -ve 2nd BC +ve Y N Antibiotics already started? Antibiotics given pre-BC? Y CVC in situ within 48 hours? CVC in situ within 48 hrs? Y N Clinical signs of infection? CVC most likely source? N Y CVC most likely source of infection? N Clinical review, consider repeat BCs Clinical signs of infection improve following removal of CVC? CVC-BSI 2nd positive culture taken from CVC blood or CVC tip after removal? (quantitative criteria) Consider SUSPECTED definition No, consider ASSOCIATED definition Yes, consider RELATED definition