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Osteoscoop - Issue N°266 – December 2012

miR-182 is a negative regulator of osteoblast proliferation, differentiation, and skeletogenesis through targeting FoxO1. Osteoscoop - Issue N°266 – December 2012. Decrease in osteoblastic proliferation and differentiation. Mesenchymal stem cell. Preosteoblasts. Osteoblasts.

anthony-whitaker
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Osteoscoop - Issue N°266 – December 2012

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  1. miR-182 is a negative regulator of osteoblast proliferation, differentiation, and skeletogenesis through targeting FoxO1 Osteoscoop - Issue N°266 – December 2012

  2. Decrease in osteoblastic proliferation and differentiation Mesenchymal stem cell Preosteoblasts Osteoblasts Decrease in bone formation Increase in apoptotic cells miR-182

  3. Decrease in osteoblastic proliferation and differentiation Mesenchymal stem cell Preosteoblasts Osteoblasts FOXO1 Decrease in bone formation Increase in apoptotic cells FoxO1 miR-182

  4. Decrease in osteoblastic proliferation and differentiation Mesenchymal stem cell Preosteoblasts Osteoblasts FOXO1 Decrease in bone formation Increase in apoptotic cells Target genes FoxO1 Protection over ROS miR-182

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