CSOPS Engineering Research Center on Structured Organic Particulate Systems

1. CSOPSEngineering Research Center on Structured Organic Particulate Systems

2. Team Goal To create a tabletop dry pharmaceutical manufacturing line to educate students K-12 on the production of pharmaceutical tablets in an interesting and safe manner

3. Individual Projects Blending Create a V-blender to mix the powder to a uniform content Roller Compaction Used to increase the particle size of the material Milling Milling is used to create a uniform particle size before powder is made into a tablet Tableting Compresses the final dosage form

4. Powder Blending Kevin Vargo Junior � ChE Young Yang Senior � MET Ryan Chesterfield Junior � MET Yody Suganda Sophomore - EE Ben Prickel Senior � EE Senior Design Andrew Johnson Senior - EE

5. Powder Blending Pharmaceutical products contain API (Active Pharmaceutical Ingredients) and non-active ingredients (excipiants) Each tablet needs to have the same amount of API to ensure quality in the drug product

6. Requirements Physical structure No larger than 2.5 ft x 2.5 ft footprint Powder material Provide a high content uniformity Must be easily loaded form the top Expelled from the bottom Automation Completely controlled automatically User interface Must be compatible for all aged students Safety Protect from dust Encase all from moving parts

7. Timeline

8. Design (CAD Drawing)

9. Current Phase Working automated blender Functional start, pause, and kill buttons Automatically stops after 15 rotations

10. Future The project should be completely finished and delivered to the project partner early next semester The only items left are testing and the safety system

11. Control Objective Objective: Develop a control circuit for the powder mixer that will� control motor and tank speed. include a simple user interface. Button for starting and stopping the motor Knob for changing the speed Kill Button to stop the process Reset Button to restart the process accomplish functions based on feedback. Display tank rotation speed Display tank revolution count Complete mixture based on completed revolutions

12. Motor Speed Control The desired speed was determined according to the ratio of Froude numbers of the V-blenders in the pharmacy lab and the blender used Froude # = w2 x (r / g) w is rotational speed r is the radius from the rotational axis to the tip g is the acceleration due to gravity Calculations produced a desired speed of 30 rpm The torque required was estimated based on the blender dimensions Torque = r x F r is the rotational radius F is the force (the weight) of the blender Estimates produced a minimum torque of 40 in-lbs.

14. User Interface Start/Stop Switch: Turns the motor on and off Motor On LED: Lights up when the motor is switched on Motor Off LED: Lights up when the motor is switched off On/Reset Pushbutton: Used to restart the process (if kill occurs, mixture completes, or at any time during the process) Kill Pushbutton: Pressed for emergency stop (Located near the tank) Speed Control Knob: Adjust rotation speed LCD Display: Displays tank speed, revolutions, and user messages

15. Feedback Circuit The feedback functions are accomplished with a shaft mount encoder attached to the shaft of the motor.

16. Future All of the programming and the circuit has been completed, but only recently due to arrival of the motor last week. The circuit needs to be incorporated securely and safely into the user control box. The motor and power supply will likely need housing to protect from powder during use.

17. Finished Product

18. Roller Compaction

20. Overview Roller Compaction is a procedure that takes small particles and compresses them into sheets or ribbons of constant density for improved milling and processing later on. Scope of Project: Deliverables: Table-Top compactor able to produce a 3mm thick ribbon from a dry-granule batch of MCC (Micro-crystalline cellulose)

21. Timeline

22. Designed rollers according to: Size of batch process (500-1000cm3) Alternate Hydraulic force (car jack) Material: cold-worked steel (machined) Designed Spindles according to: Horizontal pressure force (20mm thick) Gear box (Set-screw shaft coupling) design Motor Specifications 900 in-lbs of torque Final RPM- 7

23. Design(shown w/o motor and gearbox) 

24. Find a strong material for structural support Plexiglas casing Shim design Find a power supply Program and code Test

25. Milling Anna Harlan � Sophomore ChE Dan Prystawsky � Sophomore ChE Winnie Tan � Junior MSE Megan Benadum � Freshman ENGR

26. Background Milling Process � The purpose of milling in the pharmaceutical process is to take the product from compacting and make it (the product) ready to be taken to the tablet stage. The milling process consists of: Making the compacted particles into the correct size for the rest of the process.

27. Requirements Things to take into account when designing a mill: Way of entry from compactor Way to exit materials from machine Size/Amount of entering material Materials being milled Visibility to students (educational purpose) Safety precaution Desired exit material�s size

28. Timeline

29. Design

30. Future Work Purchase all materials Building of the mill Retrofit to assembly process

31. Questions?

32. Back-up Slides

33. Rollers

34. Shaft Coupling

35. Project Goals The milling team will: Teach children from kindergarten to high school the milling process in pharmaceutical industry. This will be accomplished by building a working replica of a mill. The mill will be part of a table top pharmaceutical process.

36. Scope of the Project This project deals with the mill only. We are in contact with the roller compacting group about how the material will be coming to us. The design will be small, it is around 5 inches in diameter and 12 inches tall total.