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Cellular Basis of Learning and Memory BIPN 148 Spring 2006 April 3-June 9, 2006

Cellular Basis of Learning and Memory BIPN 148 Spring 2006 April 3-June 9, 2006

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Cellular Basis of Learning and Memory BIPN 148 Spring 2006 April 3-June 9, 2006

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  1. Cellular Basis of Learning and Memory • BIPN 148 • Spring 2006 • April 3-June 9, 2006 • This course will examine the cellular and molecular mechanisms that underlie learning and memory. Topics covered will include the role of the hippocampus in learning and memory, neurotransmitter systems and receptors involved in learning and memory, and biochemical mechanisms of synaptic plasticity. Emphasis will be placed on discussing experiments from the primary literature. A solid background in cell and molecular biology is expected. • Prerequisites: BILD 1; BILD 2; BIBC 100/102; BIPN140 highly recommended. • Times: MWF at 4:00 • Location: CSB 001 • Web Site: http://www.biology.ucsd.edu/classes/bipn148.SP06/ • Recommended Text Ghosh and Scanziani Lecture Notes • Lecture notes are available for purchase through University Readers at http://www.universityreaders.com/students • Grading: Weekly Quizzes: 30% • Group paper and presentation: 30% • Final Exam: 40% • Grading is on a curve. • Discussion Sessions/TA office hours (optional): Pacific Hall 1115 • Wednesdays at 5:00 • Fridays at 3:00 • Contact Information • Professors: Anirvan Ghosh, Pacific Hall 1123, aghosh@ucsd.edu, 822 4142. • Massimo Scanziani, CMG 2nd Floor, massimo@ucsd.edu, 822 3839 • TEACHING ASSISTANTS: Will Barkis (wbarkis@ucsd.edu) and Mark Chen (m10chen@ucsd.edu)

  2. HUMAN MEMORY DECLARATIVE (EXPLICIT) NONDECLARATIVE (IMPLICIT) FACTS EVENTS SIMPLE CLASSICAL CONDITIONING NONASSOCIATIVE LEARNING PROCEDURAL (SKILLS AND HABITS) PRIMING EMOTIONAL RESPONSES SKELETAL MUSCULATURE REFLEX PATHWAYS MEDIAL TEMPORAL LOBE AMYGDALA CEREBELLUM STRIATUM NEOCORTEX Subdivisions of Human Memory Milner B, Squire LR, Kandel ER: "Cognitive neuroscience and the study of memory". Neuron 1998, 20:445-468.

  3. Classical Conditioning (an example of implicit memory) Ivan Pavlov

  4. Conditioned Stimulus Unconditioned Stimulus Unconditioned Response Conditioned Stimulus Conditioned Response Implicit Memory: Pavlovian Associative Conditioning

  5. TRAINING • Animal is placed in novel context • Hears a tone • Receives foot shock CONTEXTUAL TEST CUED TEST • Animal is returned to same context • Test for freezing behavior • Animal is placed in modified context • Hears a tone • Test for freezing behavior Implicit Memory: Fear Conditioning

  6. Implicit memory: Conditioned Taste Aversion A B DAY 1 1.0 1st Exposure to Food Item 0.8 0.6 grams blueberry bar 0.4 Injection of LiCl or NaCl 0.2 0.0 DAY 2 LiCl NaCl Grams Ingested on 2nd Exposure (LiCl treated group compared to NaCl treated control) 2nd Exposure to Food Item

  7. 0.8 1st Exposure to Food Item 0.6 grams blueberry bar 0.4 0.2 0.0 1st intake 2nd intake 2nd Exposure to Food Item Implicit Memory: Neophobia A B DAY 1 DAY 2 Grams Ingested (1st exposure compared to second exposure)

  8. Hermann Ebbinghaus (Distinction between short-term and long term memory)

  9. Ebbinghaus Test Memorize this set of words ZOG MIF XEL RIC DAJ NEQ SOR YAN QIJ GEB

  10. Wait for 1 minute (keep the words in mind!)

  11. Write down the words in sequence Did anyone get all 10 right?

  12. By testing subjects after various delays Ebbinghaus developed the concept of short-term and long term memory Sensory Information Working Memory/Short term Memory (Minutes) Long Term Memory (Hours/Days/Years)

  13. Working Memory Requires Frontal Lobe Function

  14. Declarative Memory Required the Hippocampus

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