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WHAT IS THE RELATIONSHIP BETWEEN POSITIVE NEUROPSYCHOLOGICAL TEST CONCLUSIONS AND FINDINGS FROM SUPPLEMENTARY NEUROLOGI

WHAT IS THE RELATIONSHIP BETWEEN POSITIVE NEUROPSYCHOLOGICAL TEST CONCLUSIONS AND FINDINGS FROM SUPPLEMENTARY NEUROLOGICAL EXAMINATIONS?. Gudrun Gudmundsdottir, M.D., Child Psychiatrist Centre for Child and Adolescent Psychiatry and Bente Gjærum. M.D., Ph.D., B.S (Ed.)

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WHAT IS THE RELATIONSHIP BETWEEN POSITIVE NEUROPSYCHOLOGICAL TEST CONCLUSIONS AND FINDINGS FROM SUPPLEMENTARY NEUROLOGI

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  1. WHAT IS THE RELATIONSHIP BETWEEN POSITIVE NEUROPSYCHOLOGICAL TEST CONCLUSIONS AND FINDINGS FROM SUPPLEMENTARYNEUROLOGICAL EXAMINATIONS? Gudrun Gudmundsdottir, M.D., Child Psychiatrist Centre for Child and Adolescent Psychiatry and Bente Gjærum. M.D., Ph.D., B.S (Ed.) Centre for Child and Adolescent Psychiatry and Regional Centre for Centre for Child and Adolescent Psychiatry. Region East and South.

  2. INTRODUCTION • Experience from previous research shows that deviant results on neuropsychological examinations performed in early childhood may indicate that the child`s problem is compatible with neurobiological dysfunction. In some cases, when positive findings from clinical and/or supplementary neurological tests is available, these findings will validate the neuropsychological conclusion. • The existing data from Bente Gjærum`s project, forms the basis for this project. In this study, we will look at the relationship between neuropsychological assessment based conclusions regarding brain integrity versus findings from supplementary neurological examinations such as CT, MR, PET, EEG, metabolic screening, chromosomes, etc.

  3. RESEARCH QUESTIONS Primary question:For how many children referral to neuropsychological examination with positive test conclusions will positive findings also be found on supplementary neurological examinations? Secondary questions: - Is there a correlation between the neuropsychological assessment based presumptions about the brain integrity (based on rules for describing tests findings which is validated empirically for older children and adults) and theresults of supplementary tests? - Given that supplementary examinations show a positive CNS finding, what is the sensitivity and specificity for each of the supplementary neurological examination techniques? - What is the positive predictive validity for the different supplementary examinations from the neuropsychological conclusion? - If these two examination methods show diverging results, what are possible explanations for this and what can the follow up studies tell us about the sensitivity and specificity of these two methods?

  4. SAMPLE • Approximately 250 children have been examined with NPM-X. • 96 of these children have been re-examined 5 years later and information on supplementary neurological examinations were then obtained. • For the rest of the total sample, similar information is collected.

  5. METHODSAND PROCEDURES • Results from supplementary examinations are partly filed in the children`s journals. In cases where such information has not been collected yet, permission will be obtained from the parents to collect this missing information. • The results on the neuropsychological assessment will be classified by Gjærum according to what degree they indicate neurobiological disturbance. • The findings from clinical neurological examinations and supplementary neurological examinations will be classified by Gudmundsdottir in a similar way. • The results from both types of classifications will be systematically compared • quantitatively (statistically) and • qualitatively, i.e. substantial analysis of the findings in the different types of examinations will be compared.

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