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NIBIB Perspective on Image-Guided Interventions Research

NIBIB Perspective on Image-Guided Interventions Research. John W. Haller, Ph.D. Acting Director, Division of Applied Science and Technology National Institute of Biomedical Imaging and Bioengineering October 19, 2006. NATIONAL INSTITUTES OF HEALTH

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NIBIB Perspective on Image-Guided Interventions Research

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  1. NIBIB Perspective on Image-Guided Interventions Research John W. Haller, Ph.D.Acting Director, Division of Applied Science and Technology National Institute of Biomedical Imaging and Bioengineering October 19, 2006 NATIONAL INSTITUTES OF HEALTH U.S. DEPARTMENT OF HEALTH & HUMAN SERVICES

  2. Outline of Talk • Definition of Image-Guided Interventions • What lead to the RFA for IGI? • Open Source Technologies • Open Architecture • Open Interface • Future Directions

  3. Image courtesy of F. Jolesz Definition of Image-Guided Interventions • All image-guided interventions require • a source of images • real-time display linked to the intervention & patient • target definition in the context of real 3D space of the patient… as distinguished from virtual image space.

  4. Image-Guided Interventions • Images used DURING intervention • Preoperative or intraoperative images are used during a procedure to guide physician to a target • Both images AND intervention must be involved • Image-guided Interventions include • Minimally invasive surgery • Image-guided Biopsy • Radiation Treatment • Image-guided radiofrequency ablation • Cryoablation • Endoscopic interventions • Other image-guided therapies

  5. Recommendations from the 2002 & 2004 IGI Workshops • A technical working group is needed to develop standardized system interfaces. • Collaborations between academia and industry should be facilitated. • Exploit grid computing and informatics infrastructure… • Heterogeneous data integration/fusion. • Platform technologies for IGI systems should be seamlessly integrated for a wide range of clinical applications…

  6. Federal Agency RetreatJanuary 2006 Standards for IGI • Standards for IGI include not only informatics standards, but also standards for IGI imaging and interventional devices. • Standards for IGI could facilitate the integration of imaging and data systems • Establish standards for data acquisition, storage, communication, software, interoperability of systems. • IGI standards will enable interoperability and plug-and-play capability.

  7. Concept for Image-Guided Interventions Initiative • Disruptive technologies • Minimally invasive IGI technologies that replace current technologies • Two-phase, 8 yr. initiative, $40M Total Cost • Phase I: 3 yr Development/feasibility studies, $300K Direct Costs Per Year • Phase II: 4-5 years in duration $750K direct costs per year • ≈ Five new IGI Centers (Cooperative Agreements) • Goal-directed, problem solving

  8. Technology Development of Image-Guided Interventions: Phase I (R21)RFA-EB-06-003 • Receipt Date: October 23, 2006 • Project period of up to three years • Direct costs up to $300,000 per year. • $5,000,000 per year NIBIB set aside • Goal is to produce disruptive technologies to replace current treatments with minimally invasive, image-guided interventions.

  9. Technology Development of Image-Guided Interventions: Open SourceRFA-EB-06-003 Reviewers will be instructed to evaluate the software dissemination plan… 1. The software should be freely available …. 2. … the software should be transferable such that another individual or team can continue development… 3. … should include the ability of researchers to modify the source code and to share modifications … 4. Commercialization … should be permissible.

  10. Technology Development of Image-Guided Interventions RFA-EB-06-003 • STANDARDS The software should adhere to community-based standards… • OPEN ARCHITECTURE • … open-architecture whose specifications are made public (i.e. the interface to other systems should be non-proprietary). • …open architecture will allow for the future integration and inter-operation of new IGI components…

  11. Technology Development of Image-Guided Interventions RFA-EB-06-003 • DATA SHARING • … data sharing plans will be considered by Program staff when making recommendations about funding …

  12. Hardware/System Access • Open technologies vs. • Open architectures vs. • Open interfaces vs. • Closed/Proprietary systems

  13. Open Source Technology • Cholera Treatment Device Device for improved set up, operation and monitoring of intravenous drip infusion systems, the only treatment for severe cases of cholera. WIRED Issue 11.11 | November 2003

  14. Open Architecture Intervention Device (e.g., Surgical Work- station or Robot) • Open architecture allows users to see inside the architecture without proprietary constraints. • All or parts of the architecture are published. Open-Source Software • … i.e., accessibility to a machine by any other machine or software.

  15. Open Interface An API that does not require royalties for access and usage is called "open." Open Interface (API) An application programming interface (API) is the interface that a computer system, library or application provides in order to allow requests for services to be made of it by other computer programs, and/or to allow data to be exchanged between them. http://en.wikipedia.org/wiki/API

  16. Open Interface Intervention Device (e.g., Robot) DaVinci Robot Tracking Device Open Interface (API) An API that does not require royalties for access and usage is called "open." Open-Source Software

  17. Disclaimer • The follow slides do not represent the views of the NIBIB, NIH or Major League Baseball.

  18. We need another quantum jump of imaging in medicine. I envision that in 30 to 40 years there will be no open surgery…there will be only image-guided microsurgery. -Elias Zerhouni, MD January 2003

  19. Future IGI Activities • Encourage the use of open source software and open architectures • Reduce health disparities both domestically and globally through new and affordable [IGI] technologies. • Establish working group for IGI standards? • Develop a Demonstration Project?

  20. Open Interface Demonstration Projects? DaVinci Robot JHU Robot Open Interface (API) Medtronic Stealthstation Brainlab Open-Source Software

  21. Reductio ad absurdum? DaVinci Robot JHU Robot Philips Scanner Siemens Scanner GE Scanner API Open Interface Medtronic Stealthstation Brainlab ITK Analyze Image Databases

  22. Summary • Continuum of hardware/system access Open-source Technology Open Architecture Open Interface Closed Proprietary • Suggested action items • Establish working group for IGI standards • Develop a Demonstration Project • What role can NIH play to promote • open architectures/open interfaces? hallerj@mail.nih.gov

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