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Relative Expression of AMH Across Developmental Stages and Its Regulation by Hormones

This study explores the expression levels of Anti-Müllerian Hormone (AMH) across different developmental stages: fetus, newborn, and adult. We present data showing the relative expression of AMH as it correlates with age in weeks and its regulation by hormones such as human chorionic gonadotropin (hCG) and follicle-stimulating hormone (FSH). Key figures illustrate the changes in AMH expression, alongside relevant hormonal influences, highlighting differences in testicular expression in both healthy and AIS patients. These findings provide insight into AMH's role throughout development.

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Relative Expression of AMH Across Developmental Stages and Its Regulation by Hormones

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  1. Figure 1 Fetus Newborn Adult ST ST ST L 3HSD L L A B C ST L ST AR L D E F ST AMH ST G H I

  2. Figure 2 A AR Relative AR expression (ratio to adult expression) weeks B AMH 24 22 16 20 21 24 25 25 38 Relative AMH expression (ratio to adult expression) 16 20 21 22 24 24 25 25 38 weeks

  3. Figure 3 A Fetus B Newborn C Adult D 150 bp 28 35 A RT- H2O

  4. Figure 4 A hCG+ rhFSH 600 600 *** 500 500 MAIS 400 400 *** AMH (pmol/l) AMH (pmol/l) 300 300 200 200 CHH 100 100 0 0 basal M1 M2 M3 Adults Neonates Umbilical Cords Time (months) B AMH immunoexpression in adult testis AIS patient AIS patient CHH patient

  5. Figure 5 A SMAT1 - + hAR-pCDNA3 110kDa B No transfected AR *** NS 3 2.5 2 Relative AMH expression (Fold induction) 1.5 1 0.5 0 - + + Forskolin 10-5 M - - + DHT 10-7 M C Transfected AR 2 *** *** 1.6 1.2 Relative AMH expression (Fold induction) 0.8 0.4 0 - + + Forskolin 10-5 M - - + DHT 10-7 M

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