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Jim Pickett, IRMA/AFC GMHC – January 23, 2013

The Bottom Line on Rectal Microbicide Research. Jim Pickett, IRMA/AFC GMHC – January 23, 2013. Today. Who is IRMA and what does she do? What are rectal microbicides and why do we need them? Brief research update Video: “The Rectal Revolution is Here” Q&A. IRMA, b.2005.

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Jim Pickett, IRMA/AFC GMHC – January 23, 2013

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  1. The Bottom Line on Rectal Microbicide Research Jim Pickett, IRMA/AFCGMHC – January 23, 2013

  2. Today • Who is IRMA and what does she do? • What are rectal microbicides and why do we need them? • Brief research update • Video: “The Rectal Revolution is Here” • Q&A

  3. IRMA, b.2005 4 people, 4 agencies, 2 countries

  4. 1200+ advocates, scientists, funders, policymakers from 6 continents AIDS Foundation of Chicago is the IRMA secretariat

  5. Mission: support development of safe, effective, acceptable, and accessible rectal microbicides for all that need them AIDS Foundation of Chicago is the IRMA secretariat

  6. Advocacy priorities • Increase and diversify funding • Increase research activities • Lubricant safety • Lubricant access • Increase knowledge • Heterosexual anal sex • Anal sex behaviours and practices in general, anal health

  7. Activities

  8. Focused projects in Africa, S. America

  9. Condoms work. So why do we need new strategies to halt the sexual transmission of HIV?

  10. What is a microbicide? • A product applied topically in the vagina or the rectum that can offer protection against HIV and, ideally, other STI pathogens • Ideally would have a contraceptive version, and another to allow for pregnancy – ARV/non-ARV • Formulated as a gel/lubricant, film, or vaginal ring • A rectal microbicide (RM) might be delivered via gel/lubricant, douche/enema or … Microbicides are still in development they are not available yet!

  11. How a microbicide works McGowan I, Biologicals, 2006 Slide courtesy Dr. Ian McGowan

  12. Anal intercourse is a human behavior.

  13. An act of unprotected anal intercourse is 10 to 20 timesmore likely to result in HIV transmission than an act of unprotected vaginal intercourse.

  14. The science

  15. Rectal microbicide research • RMP 01 – UC-781 • MTN 006 – tenofovir • MTN 007 – modified tenofovir • Project Gel underway • MTN 017 • 36 U.S. • 18 U.S. • 65 U.S. • 120/42 U.S., Puerto Rico • 186 Peru, RSA, Thailand, U.S., PR (gay, MSM, TG)

  16. MTN-017 Slide courtesy Dr. Ian McGowan

  17. CHARM Program • Combination HIV Antiretroviral Rectal Microbicide Program • Development of rectal specific ARV microbicides • Humanized mouse model • Phase 1 studies • Tenofovir • Maraviroc • Tenofovir & Maraviroc IPCP: U19 AI082637 Slide courtesy Dr. Ian McGowan

  18. Thanks to our supporters • AIDS Foundation of Chicago • amfAR – The Foundation for AIDS Research • Broadway CARES /Equity Fights AIDS • Elton John AIDS Foundation • New Venture Fund • NIH Office of AIDS Research • AVAC • MAC AIDS Foundation • Microbicide Trials Network • Population Council • Individuals - like my partner

  19. Thank YOU

  20. Showtime tinyurl.com/RectalRevEnglish tinyurl.com/RectalRevSpanish tinyurl.com/RectalRevThai

  21. @rectalmicro rectalmicrobicides.org irma-rectalmicrobicides.blogspot.com facebook.com/InternationalRectalMicrobicideAdvocates For a good time… jpickett@aidschicago.org

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