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Increased Posterior Cingulate Response in Levodopa-Treated Parkinson’s Disease Patients

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This study investigates the effects of acute levodopa on mood fluctuations in Parkinson’s disease patients. We found that patients experiencing levodopa-related mood changes exhibited heightened responses in the posterior cingulate cortex upon levodopa administration. These findings suggest a potential neural basis for mood fluctuations in Parkinson's disease, highlighting the role of the posterior cingulate in emotional processing. Further understanding of these mechanisms could lead to improved therapeutic strategies for managing mood fluctuations in these patients.

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Increased Posterior Cingulate Response in Levodopa-Treated Parkinson’s Disease Patients

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  1. Parkinson’s disease patients with levodopa-related mood fluctuations have increased posterior cingulate response to acute levodopa Kevin J. Black,1,2,3* Tamara Hershey, 1 Johanna M. Hartlein,1 Juanita L. Carl,2 Joel S. Perlmutter 2,3Departments of 1Psychiatry, 2Neurology, 3Radiology, Washington University School of Medicine, St. Louis, Missouri, USA * Introduction Methods Results Conclusions • C • S • a • W Results 1. • a Acknowledgments • S More information kevin@npg.wustl.edu

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