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Methods for Testing GxE Interaction and Effects Nonlinear Epigenetics Chicago April 18-19 2014

Methods for Testing GxE Interaction and Effects Nonlinear Epigenetics Chicago April 18-19 2014 Peter Molenaar The Pennsylvania State University.

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Methods for Testing GxE Interaction and Effects Nonlinear Epigenetics Chicago April 18-19 2014

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  1. Methods for Testing GxE Interaction and Effects Nonlinear Epigenetics Chicago April 18-19 2014 Peter Molenaar The Pennsylvania State University

  2. Molenaar, P.C.M., Boomsma, D.I., Neeleman, D., & Dolan, C.V. (1990). Using factor scores to detect G x E interactive origin of "pure" genetic or environmental factors obtained in genetic covariance structure analysis. Genetic Epidemiology, 7, 1, 93-100.

  3. Epigenetic Origins of Heterogeneity across subjects Molenaar, P.C.M., Boomsma, D.I., & Dolan, C.V. (1993). A third source of developmental differences. Behavior Genetics, 23, 519-524. Molenaar (2007). On the implications of the classical ergodic theorems: Analysis of developmental processes has to focus on intra-individual variation. Developmental Psychobiology, 50, 60-69.

  4. Subject-Specific Heritabilities Molenaar, P.C.M., Smit, D.J.A., Boomsma, D.I., & Nesselroade, J.R. (2012). Estimation of subject-specific heritabilities from intra-individual variation: iFACE. Twin Research and Human Genetics, 15, 393-400.

  5. Genetic Factor Model for Intra-Individual Variation (iFACE). Application to singlegenetically related pair (j=1,2). ymjt= mjjt+ mjCjt+ mjEjkt+ mjt jt= jjt-1+ jt Cjt= jCjt-1+ jt Ejt= kEjt-1+ jt All parameters are subject-specific. Subscript m refers to m-th phenotype.

  6. iFACE Y11(t) … Yp1(t) Y11(t+1) … Yp1(t+1) A1 (t) A1 (t+1) C1 (t) C1 (t+1) R R E1 (t) E1 (t+1) 1.0 1.0 Time t Time t+1 A2 (t) A2 (t+1) C2 (t) C2 (t+1) E2 (t) E2 (t+1) Y12(t) … Yp2(t) Y12(t+1) … Yp2(t+1)

  7. Preliminary Application iFACE to Multi-Lead EEG Data Obtained in Oddball Task

  8. Twin 1 Additive Genetic Common Environment Pz C4 P3 P4

  9. Twin 2 Additive Genetic Common Environment Pz P3 P4

  10. Heritability is high for a few leads which differ across subjects (Pz for twin 1; P3 and P4 for twin 2) The effects of common environment are high for leads neighboring the ones with high heritability (P3 and P4 for twin 1; Pz for twin 2), possibly due to A x C interaction (Molenaar et al., Genetic Epidemiology, 1990) Analogous results are obtained for other individual DZ twin pairs

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