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CALIS Medical Libraries Yinchuan Ningxia 2013

Innovation in Translational Medicine Cell-Based Therapeutics: Medicine’s Next Pillar. CALIS Medical Libraries Yinchuan Ningxia 2013. Science Flagship Publication. Over 105,000 full-text articles in the database, growing each week

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CALIS Medical Libraries Yinchuan Ningxia 2013

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  1. Innovation in Translational Medicine Cell-Based Therapeutics: Medicine’s Next Pillar CALIS Medical Libraries Yinchuan Ningxia 2013

  2. Science Flagship Publication • Over 105,000 full-text articles in the database, growing each week • Science has published articles by over 150 Nobel Laureates since 1977 • Science - 1 of 6 indicators to rank world universities for the Academic Ranking of World Universities (ARWU) • Impact Factor 31

  3. ISI Web of Knowledge 2011 Impact Factors Science Signaling: 7.5 Science Translational Medicine: 7.8 New customer discount 07% for 2014-Sci Trans Medicine

  4. Cellular Engineering: the Challenge of Controlling Cell’s Actions

  5. The Beauty of Cells • Cells naturally perform therapeutic tasks • Cell behavior is exquisitely selective • Cells are special delivery agents • Cells can handle human genetic variability • Cells behaviors can be engineered

  6. Killer Apps for Cell Therapy Will Address Critical Unmet Needs of Human Disease Immune cells that seek and destroy cancer Bacterial treatment for Crohn’s disease Combination of bacterial and mammalian cell therapeutics

  7. Roadblocks for Cell Transplants S. J. Sharkis et al., Sci Transl Med 2012;4:127ps9-127ps9 Published by AAAS

  8. Two major challenges – safety and efficacy The lifetimes of cells can be carefully controlled US FDA will need well-defined safety criteria for cell therapeutics for early movers to invest in new companies Better odds in the therapeutic development pipeline Challenges to Make Cell Therapeutics Safe

  9. Cell-based Therapeutics The New Third Pillar of Medicine? • A foundational science of cellular engineering • Key control modules needed in the cellular engineer’s toolbox • Control over cell death via safety switch mechanisms • Ability to reprogram cell communication • Systematic strategies to reshape cellular behaviors

  10. Potential Rational Engineering of Therapeutic Cells Now is the time for the designers of cellular therapeutics to take the systematic steps to lay the solid foundation for future therapeutic industries.

  11. Science Translational Medicine Research from China • Muscular Dystrophy • Peking University 2012 • Cancer Leukemia • CAS Institutes 2012 • Atherosclerosis • BGI 2013 • Graft-Versus-Host Disease • Guangzhou Medical College 2013 • Kidney Disease • Shanghai Jiao Tong University 2013

  12. Science Signaling - Research from China • Innate &Adaptive Immune Responses • CAS Laboratory of Infection and Immunity 2012 • Parkinson’s Disease • University of Science & Technology • Soochow University 2012 • Avian Influenza • Multi Institutions 2012 • Squamous Cell Carcinoma • Shanghai Jiaotong University • Capital University of Medical Sciences

  13. NEW Science Translational MedicineEducational Online Tutorial • Explore exciting content and unique features: • Navigate journal issues and articles • Search the site and more! • Visit ScienceOnline.org/tutorial

  14. scienceonline@aaas.org ScienceOnline.org/librarian and Kiki Forsythe Kforsyth@aaas.org 谢谢!

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