1. BIO 304 Review for final exam http://tmblr.co/ZUrBwxC-ohpJ

2. Overall organization of exam 30 multiple choice questions @ 2.5 points each = 75 points 16 fill-in-the-blank questions @ 2.5 points each = 40 points 6 problems @ 10 points each = 60 points TOTAL = 175 points (20% of your final grade)

3. Key terms/concepts that will NOT be on the final: Key terms 1: Reductional vs. equational division Synaptonemal complex Binomial theorem Proband Key terms 2: ABO blood groups Sex-limited and sex-influenced inheritance Genetic background Genetic anticipation Genomic imprinting Key terms 3: 2-strand vs. 3-strand vs. 4-strand exchange Lod score Tetrad analysis Ascospore Parental ditype/non-parental ditype Tetratype Key terms 4: Minimal medium Prototroph, autotroph Genetic recombination in bacteria DNA UV light absorbance DNA reassociation kinetics C0t curve Genomic library Southern blot Northern blot Western blot

4. Key terms/concepts that will NOT be on the final: Key terms 5: Primary sex ratio Secondary sex ratio Barr body Lyon hypothesis Xic VNTRs STRs SINEs and LINEs Key Terms 6: Down syndrome critical region Patau syndrome Edwards syndrome Intercalary vs. segmental deletion Compensation loop MERFF LHON Endosymbiont theory Maternal effect Key Terms 7: Wobble Sigma factor Termination factor (rho) CAAT box snRNP Branch points Key terms 8: AminoacyltRNAsynthetases Translation initiation, elongation, termination Release factor Tautomeric shift Depurination Deamination Reactive oxidant Base analog SOS repair Nonhomologous end joining

5. Key terms/concepts that will NOT be on the final: Key terms 9: Signal transduction Cyclins Cyclin dependent kinases Proto-oncogene Loss of heterozygosity Transformation RNA tumor viruses Alkylating agents Key Terms 10: Permease Transacetylase Merozygote Cooperative binding Attenuator Terminator Key Terms 11: Histone code CAAT box GC box Pre-initiation complex (PIC) TFIID TBP TAFs RITS Key terms 12: Protein domains ENCODE project Multigene family Systems biology Key terms 13: Balancer chromosome P element Conditional mutation In situ hybridization Immunofluorescence staining Conditional knock-out Targeted gene replacement (knock-in)

6. Topics to study for problems portion: • Pedigree analysis and probability calculations • Genetic crosses dealing with epistasis • Chi-square analysis of expected progeny ratios • Three-point mapping cross/linkage analysis • Restriction mapping/recombinant DNA/cloning • Parts of a gene/what’s in DNA vs. pre-mRNA vs. final mRNA • Replication transcription translation (with/without mutations) • Gene regulation/ cis-acting elements and trans-acting factors/promoters, silencers, enhancers, etc. • Polygenic traits: how many genes, contribution of additive alleles; mean, stddev, variance

7. Equations/charts/tables you will be given: Chi-square formula Probability table Codon table Variance Co-variance Broad-sense heritability Narrow-sense heritability