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A D H D. No clear indication of cause Huge amount of research Various theories & indicators Lots more work to be done So what do we know?. HEREDITY & GENES. Research reveals it runs in families Mainly genetically inherited condition Number of genes involved

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A D H D

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  1. A D H D No clear indication of cause Huge amount of research Various theories & indicators Lots more work to be done So what do we know?

  2. HEREDITY & GENES • Research reveals it runs in families • Mainly genetically inherited condition • Number of genes involved • Genes linked to neurotransmitters (chemicals) in the brain • Other possible causes include: Pre-natal and birth difficulties; alcohol/drug abuse, brain injury (cerebral palsy), lead toxicity, thyroidism

  3. Neurobiology of ADHD The Frontal Cortex is involved mainly with executive functions These include: • problem solving • attention & concentration • reasoning • planning • learning and remembering • inhibiting behaviours Frontal Cortex

  4. Neurobiology of ADHD The Limbic System controls our emotions. If over-activated it can cause: • mood swings • temper outbursts • over-activity • hyper-vigilance • abnormal sleep routine • difficulties coping with stress • poor motivation • problems with thoughts & feelings

  5. Neurobiology of ADHD The Recticular Activating System, connected to the spinal cord, is the control centre where external signals meet internal thoughts. It is the ‘key’ to turning on the brain and provides the neural connections for: • filtering & processing information • motivation • motor activity • self control • paying attention to correct task

  6. NEURON

  7. HOW NEURONS WORK Electrical signals (nerve impulses) carried by neurons (brain cells) are passed on to other neurons at junctions called synapses allowing incoming stimuli to pass from cell to cell. The signals are carried across the synapse by chemicals called neurotransmitters. Neurotransmitters fit into tailor-made receptors of the target neuron, like a key in a lock. This docking process converts the chemical signal back into an electrical nerve impulse. The brain uses over 50 different neurotransmitter chemicals. The ones affected in ADHD are Dopamine and Noradrenaline

  8. HOW NEURONS WORK

  9. NORMAL versus ADHD An enzyme called a Transporter Gene recycles unused neurotransmitters. This is known as re-uptake. In ADHD this is overactive and results in a shortage of neuro-transmitters at the synapse so transmission of stimuli (information) is restricted. For a few people the receptors are less active than they should be and do not receive the transmitted information efficiently.

  10. BRAIN DIFFERENCES • Overactive Transporter Gene(s) cause re-uptake of chemicals (neurotransmitters) - or • Receptors not working efficiently • EEG = less mature pattern of electrical activity • FMRI scans = revealed under-developed areas of brain • Extensive research has found smaller brain volume • Difficulty filtering incoming information and prioritising • Result: auditory and visual overload

  11. HOW MEDICATION WORKS Prescribed psychostimulant medications slow or block the re-uptake action of the Transporter Gene(s). More neurotransmitters allow information to pass from cell to cell more normally Where required non-stimulant guanfacine works to improve receptor efficiency

  12. TYPES OF MEDICATION Psycho-stimulants (available in UK) Methylphenidate Hydrochloride Short-acting: Ritalin, Equasym, Medikinet, Tranquilin Designed to be effective for 3-4 hrs Slow Release (XL): Equasym, Medikinet, Concerta Designed to be effective for 8 hrs & 12 hrs respectively Dexamfetamine Short-acting: Dexedrine - Effective for 3-4hrs Lisdexamfetamine Slow Release: Elvanse – Effective for 12hrs

  13. TYPES OF MEDICATION Non-stimulants Atomoxetine Sustained Release: Strattera (24hrs) Only targets Neurotransmitter Noradrenaline Guanfacine Sustained Release: Intuniv (24hrs)

  14. EQUASYM XL

  15. 50% immediate release

  16. CONCERTA XL 22% Immediate Release Outer Coating Methylphenidate Water

  17. SIDE EFFECTS Methylphenidate Hydrochloride Initial side effects may include: • Headache, upset stomach, nausea Longer-term side effects may include: • Reduced appetite • Difficulty falling asleep Rare side effects may include: • Palpitations • Rash • Bruising or swelling

  18. BENEFITS Increases: • Attention span and concentration • Short-term memory Decreases: • Hyperactivity • Impulse led behaviours Improves: • Behaviour modification and management • Remedial support and therapies • Relationships and self-esteem

  19. ENVIRONMENT-HOME Structure and routine Firm but fair discipline Consistent approach ADHD-friendly parenting style Foster and encourage resilience Be realistic in expectations

  20. ENVIRONMENT-SCHOOL Positive ethos and mutual respect Working knowledge of ADHD Good attitude and approach Determine and address cause of reaction

  21. COMORBIDITIES Associated Conditions Specific Learning Difficulties (45%) Dyspraxia (50%) Communication (60-80%) Sensory Processing 40%) Bipolar Disorder (20%) Autistic Spectrum Disorder (60-80%) Anxiety, Depression (30%) Obsessive Compulsive Disorder (30%) Mood Dysregulation Disorder (80%) Tics & Tourette’s Syndrome (50%) Oppositional Defiant Disorder (60%) Epilepsy (30%) Conduct Disorder (30%) Sleep Issues (15-50%) Asthma & Allergies (30%)

  22. POSITIVE TRAITS Warm-hearted, caring, compassionate Spontaneous, innovative, fun-loving Energetic, imaginative, risk-taker Persistent, tenacious, resourceful Willing to try new things Often highly intelligent Usually good in crisis

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