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This document provides an in-depth exploration of various reactions involving aldols and enolates, including the a-position halogenation and carbonyl reactions under weak acidic conditions. It discusses significant reactions such as the Haloform Reaction, Aldol Reaction, Mixed Aldol Reactions with both enolizable and non-enolizable aldehydes, and the use of unsymmetrical ketones. The stereoelectronic restrictions governing enol and enolate formation are examined, along with their implications in aldol-type reactions like the Michael Reaction and Robinson Annulation.
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Enol and Enolate Formation: Stereoelectronic Restrictions
Enol and Enolate Formation: Stereoelectronic Restrictions
Enol and Enolate Formation: Stereoelectronic Restrictions
Aldol-Type Reactions with Conjugated Acceptors: The Michael Reaction
Aldol-Type Reactions with Conjugated Acceptors: The Michael Reaction
Basic Disproportionation of Non-Enolizable Aldehydes: The Cannizaro Reaction