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Feocromocitoma

Feocromocitoma. Dr. Luis Humberto Cruz Contreras Residente de anatomía patológica t omatetumedicina.wordpress.com. Epidemiología. T Raro 1 por 100 000 hab Cualquier edad Pico en 5ª década 10% en niños. Esporádicos Asociados a MEN 2 (A yB ) Neurofibromatosis 1

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Feocromocitoma

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  1. Feocromocitoma Dr. Luis Humberto Cruz Contreras Residente de anatomía patológica tomatetumedicina.wordpress.com

  2. Epidemiología • T Raro • 1 por 100 000 hab • Cualquier edad • Pico en 5ª década • 10% en niños

  3. Esporádicos • Asociados a • MEN 2 (A yB) • Neurofibromatosis 1 • Sx Von HippelLindau • Sx Familiares

  4. Clínica • Resultado de Producción de catecolaminas • Hipertensión episódica / Intermitente • Ansiedad • Taquicardia • Palpitaciones • Temblor • Pérdida de peso

  5. Laboratorio • Catecolaminas • Metanefrinas • Ac. Vanililmandélico

  6. Otros • TAC • RM

  7. Macro

  8. Gross appearance of adrenal pheochromocytoma. The tumor shown in A has a markedly variegated appearance. The lower half of the specimen shown in B was fixed in Zenker fluid and has acquired the typical dark brown color indicative of a positive chromaffin reaction.

  9. Gross appearance of adrenal pheochromocytoma. The tumor shown in A has a markedly variegated appearance. The lower half of the specimen shown in B was fixed in Zenker fluid and has acquired the typical dark brown color indicative of a positive chromaffin reaction

  10. Generalmente > a 1 cm • Promedio 4 cm • Peso 90 gr

  11. Clínica • 10% Son malignos • Sobrevida a 5 años …. 50% • Sitios más comunes de METS • Ganglios, Hueso, Pulmones

  12. Patrones histopatológicos • Nidos • Trabecular • Solido • Cél. Ahusadas • Células pequeñas

  13. Histopatología • Abudante citoplasma • Finamente granular • Eosinófilo, Basofílico, Anfofílico • NO presentan cápsula

  14. Cuerpo hialinos citoplásmicos • Vacuolas • Inclusiones nucleares • Núcleo blando a pleomórfico

  15. Adrenal pheochromocytoma. A shows the typical “Zellballen” configuration, whereas B makes evident the abundant granular amphophilic cytoplasm of the tumor cells

  16. Adrenal pheochromocytoma. A shows the typical “Zellballen” configuration, whereas B makes evident the abundant granular amphophilic cytoplasm of the tumor cells

  17. Feocromocitoma Maligno

  18. IHQ

  19. Diferencial

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