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Non Classical (Unique) Actions of Hormones

Hormonex. Non Classical (Unique) Actions of Hormones. www.hormonex.com. Hormonex. Hormone Action. Non Genomic. Non Cytosolic. Non Nuclear. Genomic. Nuclear. Cytosolic. www.hormonex.com. Hormonex. Hormone Actions. www.hormonex.com. Hormonex.

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Non Classical (Unique) Actions of Hormones

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  1. Hormonex Non Classical (Unique) Actions of Hormones www.hormonex.com

  2. Hormonex Hormone Action Non Genomic Non Cytosolic Non Nuclear Genomic Nuclear Cytosolic www.hormonex.com

  3. Hormonex Hormone Actions www.hormonex.com

  4. Hormonex Receptors on Cell Membrane Complex( 1st Messenger) 2nd Messenger RNA Signal Transduction Nuclear RNA Nuclear DNA Transcription www.hormonex.com

  5. Hormonex Non Genomic - Non Classical • By activation Protein Coupled Receptors Activation of Signal Transducing Kinases Eg : MAPK – Mitogen Activated Protein Kinases Protein Transgression - Activation of Cytokines and Growth Factors to translate the Cell – Cell language of Hormone action (Hormonisation of the Milieu Interieur) www.hormonex.com

  6. Hormonex Differences with • Gender Difference - Male, Female Difference of • Estradiol,Testosterone, DHT, Androstenedione- Actions • Age Difference - Prepubertal PreAdolescent Post Pubertal & Fertility period Peri & Post Menopausal Geriatric Age www.hormonex.com

  7. Hormonex In Critical Care Medicines • Where Homeostasis is Turbulantly altered by Substrate Changes of – Inflammatory Cascade of Cytokines, Interferones, Prostaglandins & Prostacyclines & other Kinins of Cell Adhsion & Cell Apoptosis Relevance in the use of Recombnint Growth Hormone (RGH), Anti Thrombin III, Factor VII, Novo Seven in Criticare to Modulate Catabolic ,Protein loss &Healing towards - HEALING ! www.hormonex.com

  8. Hormonex We have used the Non Classical Actions of following Hormones in Clinical Medicine • Estrogen - In Osteopenia, - Arthropathies (Degenerative & Immunomodulated Types Eg :: Osteoarthritis Rheumatoid Arthritis, Psoriatic Arthritis Actions on Endothelium Osteoid Cells Osteoid Seam Vascular & Neuronal Tissues T Lymphocyties & Monocytes www.hormonex.com

  9. Hormonex Progesterone On Sperm - used in Sperm activation before AIH,ECSEI Anti Inflammatory Effects - Sensitising the Estrogen Receptors for benefits of pain Relieving effects on Bone Arthritis Boosting Immune System - Recurrent Tropical Infections like Malaria Typhoid etc - in cases of severe Epilepsy in Females Anti Epileptic – Neuro Sedative effects www.hormonex.com

  10. Hormonex Acute Care Medicine • Case of Multiple Organ Failure - in Road Traffic Accident (RTA) with Serve Head Injury • in Cerebro Vascular Accidents (CVA) with complications • of DM, CAD • in Post Traumatic Neurological Damage with Quadri & • Para Paresis (Cervical & Lumbar Disc Fractures www.hormonex.com

  11. Hormonex • Morbid Obesity • Hypothalamic Obesities with Respiratory insufficiency & • Parasomnias (Sleep Disorders) • Treated with RGH & Anti Obesity Measures • Degenerative Diseases of Skin With Acute Phase Reactions - Like Pemphigus, Psoriasis, Exfoliative Dermatitis Two Females of Pemphigus 30 & 34 Yrs Three Cases of Psoriasis with Arthritis – Males (20 to 50 Yrs) Treated with RGH & Gonadal Steroids . www.hormonex.com

  12. Hormonex • Thyroid Hormones (Non Classical Effects of ) - Used in Clinical Medicine – Specially T3 (Triodothyronine) in cases of Obesity - Growth problems (Childhood Obesity , Constitutional growth delay, Childhood Behaviour Problems like Enuresis, Strammering and Reading and Writing Defects in Dyslexia • Anti Estrogen - Used in Oncology as Promoters of Cell Apoptosis in Cencer Theropy • Estrogen, Progesterone & RGH - Given Pre and Post Operatively in Major Surgeries like Total Hip and Knee replacements (3 Cases ) – Coupled with Viscosupplementation (with Hyaluronidase) www.hormonex.com

  13. Hormonex RGH Use in Acute & Chronic Degenerative Conditions ( Actions of Anti Catabolic, Prohealing , Anti Degenerative Protiein Sparing ) • Rheumotoid & Degenarative Arthritis with High Morbidisation and Immbilisation (Knee and Hip Joints) – 3 Cases of Female Patients(40 to 55 Yrs of Peri & Post Menopausal Arthritis treated with RGH & HRT - 3 Cases of Hip and Shoulder and Knee Arthritis in Young (16 , 22, 26 Yrs) – 2 Male and 1 Female 2. Debilitating Lumbar & Cervical Dorsalgias (6 Cases of Post Menopausal Male and Female cases treated with RGH and HRT www.hormonex.com

  14. Hormonex MOF Cases (Multiple Organ Failure) • In CVA Cases Complicated with DM , CAD and Neuroipathies • (Somatosensory and Autonomic) • 1 Case of Cushing Syndrome 22 Yrs old Male in Persistent Hyperkalemia and Hyperglycimia who developed MOF in Hospital & Treated with RGH and Supportive Criticare SurvivedWith normalisation of Cortisolemia & Hyperkalemia and Hyperglycimia (MOF came as a blessing in this guys to Downregulate his Hyperactive Adrenals !!) www.hormonex.com

  15. Hormonex Reported (Hitherto ) Failure of RGH Benefits in Criticalcare Most Likely to be – Dose Related (Very High Doses were used ? And Improper selection of cases ) • Becase we have had very Encouraging Results with RGH in Creticare With use of 2 to 5 units 12 Hourly Failure in our cases was Positively Attribuble to the development of DIC & Platelet , Thrombopathies We have Subciquintly got over this problem by the concurrent use of Antithrombin III, • Propably the on going trials with Factor VII (NOVO Seven) will add to the Positive results and RGH + Amtithrombin III + NOVO Seven seem to be future Blockbuster criticare package towards decreasing Mortality in Critical Care patients. www.hormonex.com

  16. Thank You

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