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Prof. Dr. W.-H. Boehncke Dept. of Dermatology Johann Wolfgang Goethe-University Frankfurt/Main

measuring QOL in psoriasis: status quo . Prof. Dr. W.-H. Boehncke Dept. of Dermatology Johann Wolfgang Goethe-University Frankfurt/Main. the instruments. DLQI most widely used SF-36 other approaches EuroQoL 5D (EQ-5D) „self-made“ questionnaires focus on self- esteem etc.

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Prof. Dr. W.-H. Boehncke Dept. of Dermatology Johann Wolfgang Goethe-University Frankfurt/Main

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  1. measuring QOL in psoriasis: status quo  Prof. Dr. W.-H. Boehncke Dept. of Dermatology Johann Wolfgang Goethe-University Frankfurt/Main

  2. the instruments • DLQI • most widely used • SF-36 • other approaches • EuroQoL 5D (EQ-5D) • „self-made“ questionnaires • focus on self- esteem etc.

  3. Psoriasis is Third only to Chronic Lung Disease and Depression When Considering the Mental Impact of the Disease1 60 50 40 Mean Score 30 20 10 0 Cancer Arthritis Psoriasis Dermatitis Depression Congestive Heart Failure Hypertension Healthy Adults Chronic Lung Disease Myocardial Infarction Type 2 Diabetes Reference: 1. Rapp SR et al. J Am Acad Dermatol 1999; 41: 401–7.

  4. Psoriasis is Second only to CHF When Considering the Physical Impact of the Disease1 60 50 40 Mean score 30 20 10 0 Cancer Psoriasis Arthritis Dermatitis Congestive heart failure Depression Myocardial infarction Hypertension Healthy adults Chronic lung disease Type 2 diabetes Reference: 1. Rapp SR et al. J Am Acad Dermatol 1999; 41: 401–7.

  5. the results • robust finding: instruments measuring QOL indicate improvement when the disease is treated effectively

  6. Placebo 80 ‡ 70% ENBREL* 25 mg BiWk 70 ENBREL 50 mg BiWk 65% 60 ‡ ‡ 50 Mean % Improvement From Baseline 40 ‡ 30 20 10 0 2 0 4 8 12 Weeks Patient Quality of Life Significantly Improved within 2 Weeks1,2 ‡ ‡ ‡ * 6% *P = 0.0002 vs placebo ‡P < 0.0001 vs placebo References 1.van der Kerkhof PCN et al. ESDR 2004 abstract. 2.Data on file, Amgen, Thousand Oaks, Calif.

  7. the problem • Is there a correlation between the „objective“ clinical course and QOL? • Answer • The DLQI „…demonstrated the ability to detect small but meaningful changes in clinical status over time…“ Mazzotti et al., BJD 2003, 149: 318 • „DLQI and PASI improve together initially and during retreatment with etanercept“ Leonardi et al., AAD and EADV posters 2005 ???

  8. the „but“ • All it takes to „earn“ >105 € worth of treatment is to know where to put your marks on a questionnaire!!!

  9. a solution? participation

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