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Brain graphs of Women and Men

This study by Balázs Szalkai at ELTE Institute of Mathematics explores the brain from a mathematical perspective, focusing on the connectome—defined by nodes (neurons or regions of interest) and edges (axons). Utilizing diffusion MRI scans and various mathematical techniques, we analyze data from 96 healthy subjects (52 female, 44 male) aged 22-35. Our findings indicate that women's brains exhibit denser networks, higher minimum bisection width, and more efficient connectivity compared to men's brains. This research highlights the complex relationship between brain structure and gender.

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Brain graphs of Women and Men

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  1. Braingraphs of Women and Men Balázs Szalkai, ELTE Institute of Mathematics

  2. The brain from a mathematical point of view Connectome: nodes=neurons, edges=axons

  3. The brain from a mathematical point of view Macro-scaleconnectome: nodes=ROIs (regions of interest), edges=axons

  4. Computing a macro-scaleconnectome • Diffusion MRI scan • Segmentation • Parcellation • Tractography • Graphconstruction

  5. Computing a macro-scaleconnectome • Diffusion MRI scan • Segmentation • Parcellation • Tractography • Graphconstruction

  6. Computing a macro-scaleconnectome • Diffusion MRI scan • Segmentation • Parcellation • Tractography • Graphconstruction

  7. Computing a macro-scaleconnectome • Diffusion MRI scan • Segmentation • Parcellation • Tractography • Graphconstruction

  8. Computing a macro-scaleconnectome • Diffusion MRI scan • Segmentation • Parcellation • Tractography • Graphconstruction

  9. Materials and Methods • Human Connectome Project • Healthymale and femalesubjects, age 22—35 • 96 subjects (52 females and 44 males) • 83, 129, 234, 463 and 1015-node resolutions • 5 differentweightfunctions • Mathematicalanalysis

  10. Whatweknowaboutbrain and gender • Femaleshave… • smallerbrains • largergray/whiteratio • largercorticalthicknessand corticalcomplexity • Hippocampus and amygdala • Homosexualityand braincharacteristics of theoppositesex (Savic, Lindström 2008)

  11. Our results • Women’sbrains… • …havemore edgesongeneral • Densernetwork

  12. Our results • …have a largerminimum bisectionwidth • The minimum bisection ≈ separatesthe 2 hemispheres

  13. Our results • …arebetterexpander graphs • Nodegroupshave more neighbors

  14. Our results • …have more spanningtrees

  15. Conclusion • Firstapplication of graphtheoryonbraingraphs • (asopposedtonetworkscience) • Women’sbraingraphs: denser and more effectivenetworks • Notexplainedsolelybythephysicalsize of thebrain

  16. Thank you for your attention! Szalkai B, Varga B, Grolmusz V (2015) Graph Theoretical Analysis Reveals: Women’s Brains Are Better Connected than Men’s. PLoS ONE 10(7): e0130045.doi: 10.1371/journal.pone.0130045

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