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Effects of Picrotoxin Injection on Glutamate and GABA Release in Superior Colliculus

Study on the impact of intracollicular picrotoxin injection on glutamate and GABA release compared to saline, with reconstructed injection sites and dialysis probe locations in the brain. Significant changes observed.

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Effects of Picrotoxin Injection on Glutamate and GABA Release in Superior Colliculus

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  1. 160 140 120 100 80 60 40 20 0 140 120 100 80 60 40 20 0 -60 -60 -40 -40 -20 -20 0 0 20 20 40 40 60 60 80 80 100 100 A B * % of basal glutamate release SC PAG AP : -7.3 mm Time (min) C % of basal GABA release PF AP: - 4.16 mm Time (min) Figure 1: A. Effects of intracollicular injection (arrow) of picrotoxin (33 pmole/side, black diamonds) on the mean ± SEM of percentage of basal release of glutamate (upper graph) and GABA (lower graph) as compared to saline injection (open squares). * p< 0.05 picrotoxin vs saline, ANOVA, n=4. B. Reconstruction of the injection sites in the caudal superior colliculus on an identified coronal section modified from the atlas of Paxinos and Watson. PAG : periaqueductal grey; SC : superior colliculus. C. Reconstruction of the location of the dialysis probes in the parafascicular nucleus on an identified coronal section modified from the atlas of Paxinos and Watson. PF : n. parafascicularis; VPM : ventroposteromedial nucleus of the thalamus.

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