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Antisense

Antisense. When RNase cleaves mRNA the oligo can be reused. Antisense. Assuming linear target. Antisense. Usually don’t do anything with bases b/c of base pairing issues. Antisense. normal. Base on opposite side of sugar. Antisense. 2’-OH replaced with -OMe. Antisense. chiral.

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Antisense

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  1. Antisense When RNase cleaves mRNA the oligo can be reused

  2. Antisense Assuming linear target

  3. Antisense Usually don’t do anything with bases b/c of base pairing issues

  4. Antisense normal Base on opposite side of sugar

  5. Antisense 2’-OH replaced with -OMe

  6. Antisense chiral nonchiral Popular, nuclease resistant, can get in cell cell permeable

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