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IP 3 R1

CaM-Seph. CaM-Seph. + Suramin. + Suramin. Seph. Seph. Input. A. IP 3 R1. B. EGTA. Ca 2+. IP 3 R1 1-225. EGTA. Ca 2+. A. P 49-81. B. P 106-128. a b c d e f g h. a b c d e f g h. EGTA. Ca 2+. 0. 12.5. 25. 37.5. 50. 75.

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IP 3 R1

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  1. CaM-Seph CaM-Seph + Suramin + Suramin Seph Seph Input A IP3R1 B EGTA Ca 2+ IP3R1 1-225 EGTA Ca 2+

  2. A P 49-81 B P 106-128 a b c d e f g h a b c d e f g h EGTA Ca2+ 0 12.5 25 37.5 50 75 100 0 12.5 25 37.5 50 75 100 [Suramin] (µM) [Suramin] (µM) C D

  3. 1499 1649 100 % 1-5-8-14 76 % IQ 60 % IQ 72% 1-5-8-14 A 1554-ldsqvnnlflkshnivqkta-1573 1554-ldsqvnnlflkshnivqktalnwrlsarnaar-1585 1564-kshnivqktalnwrlsarnaar-1585 1564-kshnivqktalnwrlsarnaarrdsvlaasrd-1595 (b) (c) (d) (e) B C a b c d e a b c d e Ca2+ EGTA D CaM P1554-1573 P1554-1585 P1564-1585 P1564-1595

  4. 0 12.5 25 50 75 100 [Suramin] (µM) A a b c d e f g EGTA Ca2+ B

  5. A Lvec L15 B C

  6. A B

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