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Innovative PCPCSK9 Rename: LDLC-Modulating Compound Analysis

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Analyzing Relative Amounts of NPCSK9 and sPCSK9 against LDLR with Simvastatin treatment at varying concentrations in µM.

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Innovative PCPCSK9 Rename: LDLC-Modulating Compound Analysis

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  1. A ProPCSK9 Non- specific mPCSK9 * 2.0 * * * * * 1.5 Relative Amount 1.8 1.7 1.0 1.6 1.5 1.4 1.3 0.5 1.1 1.1 1.0 1.0 1.0 1.0 0.0 0 0.01 0.05 1 5 10 B sPCSK9 2.0 2.0 1.5 1.5 C Relative Amount 1.6 1.6 1.0 1.0 LDLR 1.5 1.5 1.5 1.5 1.4 1.4 0.5 0.5 * 1.0 1.0 1.0 1.0 * 3.0 3.0 3.0 3.0 0.0 0.0 2.5 2.5 2.5 2.5 0 0 0.01 0.01 0.05 0.05 1 1 5 5 10 10 10 * 2.0 2.0 2.0 2.0 Relative Amount 2.6 2.6 2.6 2.6 2.6 2.6 2.6 2.6 1.5 1.5 1.5 1.5 2.0 2.0 2.0 2.0 1.0 1.0 1.0 1.0 1.1 1.1 1.1 1.1 0.5 0.5 0.5 0.5 1.1 1.1 1.1 1.1 1.0 1.0 1.0 1.0 0.0 0.0 0.0 0.0 0 0.01 0.01 0.01 0.01 0.05 0.05 0.05 0.05 1 1 1 1 10 10 10 10 5 5 5 5 Simvastatin µM

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