Agracopper

1. TM Agracopper CERTIFIED QUALITY A Concentrated Form of Refined Copper Micro-Encapsulated Organic Acids and Essential Oils Manufactured by AGRANCO CORPORATION USA

2. Distribuidores AGRANCO Central Offices AGRANCO World Distribution Network Agranco Group is a manufacturing and sales organization headquartered in Coral Gables, Florida and manufacturing companies located in Mexico and the U.S. It has a network of distributors in Mexico, United States, Central America, South America, Europe, Middle East, Africa and Asia, all dedicated to providing distribution and service of our products, with its own staff of engineers, technical specialists and PhD in every area of activity. Animal Nutrition: Selective Adsorbents Mycotoxins, Organic Minerals microencapsulated probiotics and Immunomodulators, Enzymes, Yeast and Microflora regulators. Agricultural Industry: Organic Insecticides, Fertilizers, natural and biodegradable. Aquaculture Industry: Yeast, Enzymes, Probiotics and oligosaccharides for shrimp and fish rations. Food Processing : Disinfectants food for human consumption. Sugar Industry : Stabilizers of pure cane juice Water Treatment : Decomposers of organic matter and water purification. The products are marketed under its own brand, are unique and specific to improving processes in each industry, having fully researched about them, proving their effectiveness in every field. We invite you to evaluate waiting to exceed your expectations and be part of our user list. The good actions of today make for a better tomorrow AGRANCO Distributors Worldwide AGRANCO

3. About Copper and Agracopper • There is currently a tremendous amount of research going into antimicrobial  effects of copper. It is believed that copper has the ability to kill harmful bacteria through a multi-faceted approach. The thought is that contact of the bacterium with the surface damages the cell membrane, or outer envelope of the cell by several mechanisms. This makes the bacterium “leaky” as it loses • water and with it, many soluble essential nutrients and salts. Furthermore, copper ions released from the surface can enter the cell uninhibitedly and by this action will help to enhance the effect of AGP used in the Feed. In addition, this supports our innovative concept of Agracopper which protects the copper sulfate from forming complexes with other minerals in the feed and dissociation in the Stomach. • The multi-target effect of Agracopper makes resistance extremely unlikely as copper ion kills bacteria very quickly and leaves almost no survivors. This is due to the fact that there is neither the time for bacteria to “learn” how to resist copper or the possibility to pass on any knowledge to a significant population of survivors. Copper remains essential to bacteria and bacterial resistance is typically observed against non-essential components such as  many of the antibiotic growth promoters in animal Feed. Resistance to copper ion, which is recognized by the cell as a needed nutrient, is extremely unlikely.  • Finally , we are very confident that Agracopper in poultry feed will act to potentiate the effectiveness of AGP , to further increase gut health and lower the incidence of Necrotic Enteritis. • Diarrhea Control, ImmunityModulation, • and AntibioticsReduction • Typically, forthispurposethedietscontain zinc oxide and/orcoppersulphate as • sourcesforinorganicminerals. • They are added in greatquantitiesbecausethey re-combine and about 75% to • 95% islost in thedigestivetract, byexcretingtotheoutside, losing and creating • contamination and badodor in theenvironment. • - Its use alsooccupiesmuchspace in the formula. • Thisalsoaffectsacidityonthestomach of the • monogastrics. • TheReasontoMicroencapsulate • the Cooper Sulphate (Agracooper) • Themetabolism and Cu’sabsortionisaffectedbyMolybdenum,Sulfur, Calcium, • Iron, Manganesium, Zinc, Cobalt, Lead, Cadmium and Selenium. • - Formationof unavailablemolybdates, which are generated in thestomach/ • proventriculusduetotheinteractionbetweenmolybdenumwithcopper and • sulfur, reduce theavailability of Cu duetoitstransformationintocopper sulfure • (J. Benitez 2011). • Withthe use of aasynthetic, theabsortion of CU can becomedepressed (D. • Mahan, et. al., 2010). • Agracopper, whilebeing 100% protected, doesnotsuffer loses byinteractions • withotherminerals and thesyntheticaa in diets. Agracopper Certified Quality

4. Cooper Sulphate vs. Agracopper • Frequentlycoppersulphateisincluded as a promoter of growthorfungicide • becauseitisveryeconomical, applying 500 grams of coppersulphate (125 g of • copper) bymetric ton MT. In case of severeinfectionscausedbyfungus, you • getto use 1 kilogram of coppersulphate (250 g of cooper) by MT. • Itisreportedthatlevels of 250 ppm of Cu, already can cause poisoning in • poultry and thepresence of gizzard’serosion. (M. Contreras y D. Zaviezo). • Gizzard’serosion (GE)..…can be causedbypresence of micotoxins in thefeed, • polisaturatedacids, highlevels of cooper, dietsdefficient in Vitamin K and • defficiency in methionine, amongothers. • - Jensen et al.(1991) induced oral lesions in poultrywhilesupplementingcopper • sulphite in diets. Incidence and severity of the oral lesionsshowed a linear • increase as thecoopersulphate’sconcentrationswereincreased. Severity of • GE alsoincreasedwiththeconcentration of coopersulphate. • Vitamins are byfarthemostlabilenutrientssincethey are harmed at a greator • lowdegreeby a variety of factors, such as: • Heat, Light, Oxigen, Acids, Alcaloids, ReducingAgents, OxidatingAgents, • metallicagents, etc. • Vitamin B1isunstableto pH neutral and alcaline pH, catalyzedbymetallicions • such as cooperand totallydestroyedbysulphites… vitamin C isthemost • sensitive of vitamins, itislabile in presence of metallicionsspeciallycooper • (J. King y S. de Pablo, 1987). • SelectingtheSource of Cooper Sulphite • Whencoopersulphiteisused, itisextremelyimportanttoselect a goodsource • whichdoesnot cause lumps, thusavoidingmistakesuponweighing and • blendingwhich can provokeanexcessiveingestion. • Precautions: • - A goodqualityproduct (free of dyoxine and heavy metals). • - Concentration (Pentahydrated: Cu 25.4 and S12.8 (+/- 6)) • - Free fromlumps (Notmatteddown), exactweighing and perfectblend. Certified Quality Agracopper

5. Pancreas Liver Ceum Esophagus Rectum Stomach Duodenum Colon Smallintestine (jejunum, ileum) The lipid matrix protects it upon passing through the stomach and slowly releases it, through the extension of the small intestine and other elements which really affect the traditional cooper sulphate. This allows the effect of copper sulphate to take place throughout the small and large intestine, and upon being slowly released, it has a maximum effect in the intestinal microflora. Agracopper virtually is not excreted to the outside, thus reducing contamination of the environment. It does not affect acidity of the digestive tract on monogastrics. Agracopper Digestibility Pathogens Certified Quality pH

6. Virus capsid CAMs of the host cells. • Agracopper • Sinceitismicroencapsulated in a lipidmatrix, palatibilityproblems are eliminated. • More effective in the control of diarrhea by reducing the need for antibiotics and • growth promoters. • Its effect is complete along the entire small and large intestine. • Antibacterialeffect of Agracopper • A highlevel of inclusion of Zn and Cu diminshestheactivity of • pathogens bacteria. (Ole Hojberg et al, 2005). • Bivalentcations of Zn ion (Zn ++) and Cu (Cu ++) seemtohaveanaffinitywiththelinkingsites of E.coli. • Zn ion and Cu, preferably link toglycoprotein and toglycolipid of the intestinal wall, whichpresentnegativecharges. • E. colicannotfindanyunionsitetoadhere, penetrate and generatetoxicity in thetissue in question. • Forthispurposethe zinc/cooper ion shall be easilyreleased at theproper time and place. • HowDoesAgracopperWork in the TGI? • Antiviral Effect and ExcessiveImmune • Response of Agracopper • The Cell Adhesion Molecules (CAMs) are proteins located on the cell surface involved in the process of adhesion to other cells or the extracellular matrix in a process called "cell adhesion". • Cu ions get to block the joints between the Virus and the cell membrane’s CAMs, thus reducing the infection of epithelial cells in the intestine. • On the other hand, once the ions adhere to CAMs, they  can also block the joints between them and the immune cells that cause inflammation, regulating the flow of these cells to the intestinal epithelium thus preventing allergies due to excessive immune responses. Certified Quality Agracopper

7. Agracopper Copper Sulphate- 70% Copper Sulphate Micro-Encapsulated Product Data Sheet Premix for Usein Animal Feed Composition 100% By-Pass action in the stomach. Prevents interaction with HCL present in the stomach. For every 100gr. content: Active Material:Copper Sulphate 70% Coating Material:Hydrogenated Vegetable Oil Progressive liberation of copper due to the degradation of the vegetable matrix by pancreatic lipase. Characteristics Agracopper is a micro encapsulated Copper Sulphate supplement. The micro encapsulation ensures a more effective release of copper in the gastro intestinal tract of the animal. Copper Sulphide, the principal component in Agracopper contributes to improved production performance and prevention of diarrhea in piglets Mode of Action Due to the progressive liberation of free copper ions in the intestine where it’s needed, the copper effect is improved dramatically. The lipids of vegetable origin that form the coating of Agracopper are degraded by pancreatic lipase when the product reaches the duodenum. Subsequently the copper is slowly liberated in the small intestine. In this way, the distal part of the small intestine becomes the place for obtaining micro flora modulating effect. The continous liberation of free copper ions accomplishing the better control of harmful bacteria.

8. Agracopper Copper Sulphate- 70% Properties Product Properties: Appearance: Granular, free flowing powder Color: Light Blue Odor: Characteristic, Slightly sweet fatty acid Physical Properties: Moisture: <3% Particle Size: Uss 20(850u) .05% Max Temperature of maximum 90-95 C° when coating is melting Additional Information Presentation: Polyethelene bags in 20kg boxes or 50kg drums. Storage: Store in dry place, ambient moderate temperatures, in closed packaging when product is not being utilized. Shelf Life: Best before 12 months from date of manufacturing. GMO: All the ingredients used in the manufacturing of Agracopper is Non-GMO Doses accordingto species Swine:Weaningpiglets25-80g/MTofcompletefeed.Otherpigs300g/MT Layers,Broilers, &Turkeys: 50-100 g/MT of complete feed. Dairy Cattle:12g of Agracopper per head, per day. All ingredients approved by FDA under the American Association of Feed Control Officials under Official AAFCO N° 57.150. Publication: 1,998 Country of Origin USA Manufacturer and Worldwide Distributor AGRANCO CORP. USA 2655 South Le Jeune Rd. Suite 805, Coral Gables, FL. 33134 Tel (305) 856 3782 Fax (305) 856 3734 E mail: agranco@agrancousa.com