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adc antibody drug conjugate

BOC Sciences provides antibody drug conjugates services and related products for people from all the world.<br>https://adc.bocsci.com/<br>

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adc antibody drug conjugate

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  1. Featured Services Antibody Modification and Conjugation Technologies ADC Payloads Development ADC Analysis and Characterisation Cysteine Conjugation The most basic immunoglobulin G molecule consists of two light chains and two heavy chains connected by non-covalent binding forces and disulfide bonds. The two heavy chains are connected by a disulfide bond in the hinge region (hinge region). The disulfide bond connecting the two heavy chains in the hinge region can be specifically cleaved by reducing agents such as MEA, dithiothreitol (DTT) and tris (2- carboxyethyl) phosphine (TCEP) to generate two Half-antibody molecules, each containing an antigen-binding site. Learn More Lysine Conjugation A humanized antibody contains 80 to 90 lysins, so modification of partial lysine has no effect on the natural disulfide bond, nor does it significantly change the stability, biophysical properties, or affinity of the antibody. However, through lysine conjugation, each antibody will be coupled with 0~8 small molecule drugs, and the location of the coupling may occur on nearly 40 different lysine residues on the light and heavy chains of the antibody, and more than 1 million ADCs will be generated. Learn More Featured Products ADCs Cytotoxin with Linkers

  2. ADCs Cytotoxin ADCs Linker Our Capabilities BOC Sciences has been committed to providing customers with high-quality products and services for antibody-drug conjugate research. Our unparalleled platform and outstanding drug discovery expertise allow us to provide you with comprehensive data and unique insights to provide you with the depth and breadth of science to advance your drug discovery program. Who We Are About Us BOC Sciences offers customers with comprehensive one-stop-shop of all aspects in antibody-drug conjugate (ADC) research and evaluation, ranging from antibody modification and conjugation technologies, ADC payloads development, payload- linker synthesis, ADC conjugation, to various stages of ADC characterization and manufacture. Furthermore, we also provide an extensive list of linkers, payloads and payload-linker sets. https://adc.bocsci.com/

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