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Pharmacology Training Programs in the Future

This document explores major accomplishments in pharmacology over the years, including key discoveries such as G-proteins, ANP, and Zidovudine's effectiveness against HIV. It highlights the interconnections between pharmacology and other disciplines, including biochemistry, genetics, and systems biology. The discussion extends to the education and curriculum needs for future pharmacologists, emphasizing collaboration with industry and enhancing translational research initiatives. Insights into the drug development process and the importance of interdisciplinary training are crucial for the next generation of pharmacology professionals.

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Pharmacology Training Programs in the Future

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  1. Pharmacology Training Programs in the Future

  2. Major Accomplishments in Pharmacology and Impact of other disciplines. (partly from ASPET’s “Significant events in Pharmacology”) 1978 - Discovery of G proteins - biochemistry 1981-1983 - ANP - physiology/biochemistry 1988 - ANP receptor Guanylyl Cyclase - biochem/mol. biology 1987 - Zidovudine effective against HIV - virology/immunology Late 80’s to 90’s - Structures of G proteins (ras, Gi, Gs, G) biochem/structural biol 1997 - structure of adenylyl cyclase - biochem/structural biol 2000 - structure of rhodopsin (GPCR) - biochem/structural biol 90’s - current - transgenics and knock outs - genetics/mol. biol./physiol/pathology.

  3. Systems Biology Mathematical Modeling Pharmacogenomics Molecular Biology Biochemistry Cell Biology Chemistry Immunology Microbiology Physiology Structural Biology Genetics Proteomics Astrophysics Pharmacology

  4. Pharmacology Students/Postdocs Other (writing Patent law, etc) Industry Academia Govt. (CDC NIH, etc.) Administration Science (R&D) Teaching

  5. Needs on curriculum: How much do we teach? • What do we teach? • More Biochemistry? Proteomics? • Systems Biology/ Computational Biology (Mathematical • Modeling)? - Collaborations with biology/math depts. • joint programs? • Small molecule screens? (interactions with industry) • Intellectual Property and Patenting? (ditto) • More genomics/genetics? • Structure based inhibitors/activators? Structural Biology? • Administration? Ph.D/MBA programs?

  6. Enhance the translational side of research Collaborations with Clinicians (co-mentors/committee members) - insights into clinical trials Collaborations/Partership with Industry (scholarships/fellowships) Co-mentors in Industry? Advantages: Learn hands-on the processes that contribute to drug development - analyses of clinical trial data Gain insights into the nuances of how Industry works - from data books, proprietary rights, to research priorities. Make informed decisions about careers in industry. Hurdles: Time away from primary lab Delay in publications! Commitment on part of industry? - investment?

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