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High and Consistent SVR Rates with BI 201335 in Treatment-Naïve HCV Genotype 1 Patients

The SILEN-C1 trial demonstrates that treatment with the second-generation HCV protease inhibitor BI 201335 results in high and consistent sustained virologic response (SVR) rates among treatment-naïve patients with HCV genotype 1. This research analyzes various baseline factors, including age, gender, ALT and GGT levels, HCV RNA, subtype, and IL28B, to identify predictors of SVR. The findings highlight the effectiveness of BI 201335 and its potential to improve outcomes for patients with HCV genotype 1.

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High and Consistent SVR Rates with BI 201335 in Treatment-Naïve HCV Genotype 1 Patients

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Presentation Transcript

  1. Treatment with the second-generation HCV protease inhibitor BI 201335 results in high and consistent SVR rates:Results from SILEN-C1 in HCV genotype-1 treatment-naïve patients across different baseline factors

  2. Disclosures

  3. Introduction

  4. SILEN-C1 trial

  5. Virologic responsea

  6. Methods

  7. Baseline characteristics

  8. Virologic response by age and gender

  9. Virologic response by baseline ALT and GGT

  10. Virologic response by baseline HCV RNA

  11. Virologic response by HCV GT-1 subtype

  12. Virologic response by IL28B

  13. Baseline predictors of SVR

  14. Baseline predictors of SVR

  15. Discussion

  16. Acknowledgements

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