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The Swedish Twin Registry - STR

The Swedish Twin Registry - STR. HISTORY Started by Lars Friberg and Rune Cederlöf in the late 1950s Church records of twin births 1886-1925 All identified same sex twins contacted during the 1960s

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The Swedish Twin Registry - STR

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  1. The Swedish Twin Registry - STR HISTORY • Started by Lars Friberg and Rune Cederlöf in the late 1950s • Church records of twin births 1886-1925 • All identified same sex twins contacted during the 1960s • Today: all alive Swedish born twins aged 10 or more have been contacted and invited to participate

  2. STR leadershiporganization • STR steering group: • Patrik Magnusson (director) • Nancy Pedersen • Paul Lichtenstein • Martin Schalling • CatarinaAlmqvist • Maria Feychting • Johan Askling • Sofia Carlsson • Magnus Johannesson (representative from the National Council) • National council: Representatives from: • Lund University • Göteborg University • Örebro University • Jönköping University • Linköping University • UmeåUniverstiy • Handelshögskolan Stockholm

  3. Funding • Run as a KI core facility • Economic support from the Swedish Research Council 2018-2022

  4. Birthcohort 1985-1986 1959-1985 1926-1958 1886-1925 1960 1970 1980 1990 2000 2010 Full-cohortcontacts and Bio-sampling No Bio-sample Blood Saliva 1993-- 1986-1992

  5. Current invitation/recruitment into STR • Since 2004 we contact parents to Swedish born twins when the twins turn 9 years of age • Invitation to participate in STR – broad consent • Screen for somatic and mental health problem • High participation rate (70%) • Follow-ups at 15, 18 and 24 years

  6. Recent landmarks • All adult Swedish born twins have now been contacted for participation when 10 years or older with general questionnaire and DNA donation request • 200 000 in the register • 160 000 have zygosity • The largest twin register in the world

  7. Data • Paper questionnaires • Telephone interviews (SALT 1998-2002) • Web questionnaires (2005 and onwards) • Health check-ups (TwinGene, CATSS, SATSA) • Health registers (National Board of Health and Welfare) • DNA (N=60 000) • GWAS (N=40 000) • Serum (N=15 000) • Blood biochemistry (TwinGene, SATSA) • Computer tests (cognition, time-consistency)

  8. GWAS (Illumina) • Older twins, born 1911-1958: • N = 20 000 • Genotyped in Uppsala (SNP&SEQ Tech) 2008, 2011, 2015 • Twins born 1959-1993 (ongoing) • N = 13 300 • Genotyped in Uppsala (SNP&SEQ Tech) 2018 • Younger cohort, born 1994 and onwards (ongoing) • N = 17 000 • Genotyped in Uppsala (SNP&SEQ Tech) 2015, 2018

  9. Serum measurements • All of TwinGene (N=12600) • HDL, LDL, TC, TG, CRP, Hb, HbA1c, Glucose, ApoA1, ApoB • ACPA (Lars Klareskog) • Total IgA (LennartHammarström) • Creatinine, Cystatin C (Per Svensson) • Pepsinogen I/II, H.pylori (Weimin Ye) • Subsets • LpPla2, aPC, aOxCl (Ulf de Faire, Johan Frostegård) • PCSK9, APOC3 (Ferdiand Van T Hooft) • Proteomics (SciLife Lab Protein atlas) • Metabolomics (HPLC Mass spec) Serum is an available but limited resource!

  10. Epigenetics in twins • Key observations: • Gene expression differs between cell types within individuals • Discordant MZ twins • Gene expression influenced by environment • Epigenetic measures: • DNA methylation, histone acetylation etc. • Confounding from Genetics: • MZ twins may provide remedy!

  11. Apply for new STR projects • STR steering committee meets 4 times/year • Short application + CV + ethics permission Where? https://ki.se/en/research/swedish-twin-registry-for-researchers • Metadata + questionnairesaccessible for free • Blood, serum and DNAstored in biobank • Phenotypes

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