1 / 7

Antibacterial Polyelectrolyte Multilayers for Improved Implantable Medical Device Safety

This research explores the innovative use of antibacterial polyelectrolyte multilayers (PEMs) in implantable medical devices such as pacemakers and defibrillators. With significant potential to reduce bacterial exposure—addressing the 6% infection rate in vascular surgeries—PEMs are fabricated layer-by-layer, utilizing poly(allylamine hydrochloride) and poly(acrylic acid). Key factors such as film thickness, interpenetration, and pH control are optimized to enhance device performance and biocompatibility, paving the way for safer surgical outcomes.

brenden-pope
Télécharger la présentation

Antibacterial Polyelectrolyte Multilayers for Improved Implantable Medical Device Safety

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Antibacterial Polyelectrolyte Multilayers (PEMs) Team X Maricela Delgadillo Kay Furman Yushan Kim

  2. Industrial Application • Implantable Medical Devices: • Pacemakers treat Bradycardia (slow heart rhythm) • Size: 45x48x8 • Defibrilators treat Tachyarrhythmia (fast heart rhythm) • Size: 62x51x15mm • Potential for Bacterial Exposure • 6% of all vascular surgeries result in surgery site infection (Health Protection Agency) • Packaged and handled sterilely • 1-2 hr surgical procedure Images from http://www.medtronic.com/

  3. Brief PEM Background • Layer-by-layer fabrication • Polycation - Poly(allylamine hydrochloride) PAH • Polyanion - Poly(acrylic acid) PAA • Easy to control pH and number of bilayers • Polyelectrolyte pH affects: • Film Thickness • Interpenetration between layers • Highly ionized polyelectrolytes (pH~6.5) result in thin films • Possible cell adhesion applications • pH~3.0 loopy conformations

  4. Project Plan sepidermidis.mlst.net/ Berg, 2000

  5. PEM Design • TiO2 substrate: + charge • 1st PEM layer: PAA • PAH/PAA bilayers • Incorporation of antibacterial active by use of electrostatic charge • Other design considerations • Porosity • Cross-linking

  6. Ti disk Staph aureus Potential Material Issues • Metal substrate and PEM processing • Titanium use in implantable devices • Previously published studies with metal • PEM on device stimulation electrodes (Patent 5964794, 1999) • PEMs for corrosion-resistant metals (Patent 027011, 2003) • Necessitates (-) PAA layer deposition first • Imaging Issues • Microscopy requires transparent substrate • TEM or SEM availability

  7. Further Issues and Questions • Feasibility of bacteria/eukaryote selectivity

More Related