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ATP of Skeletal Muscles

Energy of Skeletal Muscles Lecture -3. ATP of Skeletal Muscles . Objectives. Recognize the importance of ATP as energy source in skeletal muscle. Understand how skeletal muscles derive and utilize ATP for energy. Differentiate between energy metabolism in red and white muscle fibers. ATP.

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ATP of Skeletal Muscles

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  1. Energy of Skeletal Muscles Lecture -3 ATP of Skeletal Muscles

  2. Objectives Recognize the importance of ATP as energy source in skeletal muscle. Understand how skeletal muscles derive and utilize ATP for energy. Differentiate between energy metabolism in red and white muscle fibers.

  3. ATP ATP or adenosine triphosphate is the energy currency used by our body everyday to perform a number of tasks: • Maintain body temperature • Repair damaged cells • Digestion of food • Mechanical work – movement • ATP↔ ADP + Energy

  4. ATPis the most important form of chemical energy stored in cells Breakdown of ATP into ADP+PO4 releases energy. Muscles typically store limited amounts of ATP – enough to power 4-6 seconds of activity So resting muscles must have energy stored in other ways. ATP

  5. Systems of generation of ATP The process that facilitates muscular contraction is entirely dependent on body’s ability to provide & rapidly replenish ATP 1- ATP-Ctreatine Phosphate system 2- Glycolytic system 3- Oxidative system

  6. INTERACTION OF ENERGY SYSTEMS Immediate Short-term Long-term

  7. Energy Transfer Systems and Exercise 100% % Capacity of Energy System Anaerobic Glycolysis Aerobic Energy System ATP – Creatine Phosphate 10 sec 30 sec 2 min 5+ min Exercise Time

  8. Energy systems for muscular exercise

  9. Energy requirements The three energy systems often operate simultaneously during physical activity HOWEVER Relative contribution of each system to total energy requirement differs depending on exercise intensity & duration Magnitude of energy from anaerobic sources depends on person’s capacity and tolerance for lactic acid accumulation (Athletes are trained so that they will have better tolerance for lactic acid) As exercise intensity diminishes & duration extends beyond 4 minutes, energy more dependent on aerobic metabolism

  10. Fatigued muscle no longer contracts due to: 1- Accumulation of lactic acid (low pH of sarcoplasm) 2- Exhaustion of energy resources ( ADP &  ATP) 3- Ionic imbalance: muscle cells is less responsive to motor neuronal stimulation Muscle Fatigue

  11. What are the mechanisms by which muscle fibers obtain energy to power contractions?

  12. Muscles and fiber types White muscle : (glycolytic) mostly fast fibers pale (e.g. chicken breast) Red muscle: (oxidative) mostly slow fibers dark (e.g. chicken legs) Most human muscles are: Mixed fibers pink

  13. Fast Vs. Slow Fibers Type I Type II

  14. Abundant mitochondria Extensive capillary supply High concentrations of myoglobin Can contract for long periods of time Fatigue resistant Obtain their ATP mainly from fatty acids oxidation by TCA cycle & ETC (oxidative phosphorylation) Slow fibers

  15. Large glycogen reserves Relatively few mitochondria Produce rapid & powerful contractions BUT of shortduration Easily fatigued Obtain their ATP mainly from anaerobic glycolysis Fast fibers

  16. ENERGY REQUIREMENTS AND SOURCE OF ENERGY FOR SKELETAL MUSCLE( Resting vs. Working)

  17. ATP use in the resting muscle cell During periods of muscular rest ATP is required for: 1- Glycogen synthesis (glycogenesis) i.e. storage form of glucose to be used during muscular exercise 2- Creatine phosphate production i.e. energy storage compound to be used at the beginning of muscular contraction

  18. Source of ATP in resting muscle fibers Resting muscle fibers takes up free fatty acids from blood. Fatty acids are oxidized (in the mitochondria) to produce acetyl CoA& molecules of NADH & FADH2 Acetyl CoA will then enter the citric acid cycle (in the mitochondria)ATP, NADH, FADH2 & CO2 NADH& FADH2will enter the electron transport chain.  synthesis of ATP

  19. RESTING MUSCLE FIBERS METABOLISM Figure 10–20a

  20. ATP sources in working muscle At the beginning of exercise, muscle fibers immediately use stored ATP For the next 15 seconds, muscle fibers turn to the creatine phosphate. This system dominates in events such as the 100m dash or lifting weights.

  21. ATP sources in working muscle cont. After the phosphagen system is depleted, the process of anaerobic glycolysis can maintain ATP supply for about 45-60s Glycogen stored in muscles  Glucose  2pyruvic acid + 2 ATPs 2 Pyruvic acid  2 lactic acid Lactic acid diffuses out of muscles blood  liver  Glucose (by gluconeogenesis) blood  muscles * It usually takes a little time for the respiratory and cardiovascular systems to catch up with the muscles and supply O2 for aerobic metabolism.

  22. WORKING MUSCLE FIBERS METABOLISM Figure 10–20c

  23. Anaerobic metabolism is inefficient: 1- Large amounts of glucose are used for very small ATP returns. 2- Lactic acid is produced leading to muscle fatigue Type of sports uses anaerobic metabolism? Sports that requires bursts of speed and activity e.g. basketball. ATP sources in working muscle cont.

  24. Aerobic metabolism occurs when the respiratory & cardiovascular systems have “caught up with” the working muscles. During rest and light to moderate exercise, aerobic metabolism contributes 95% of the necessary ATP. Compounds which can be aerobically metabolized include: Fatty acids, pyruvic acid (made from glucose via glycolysis) & amino acids. ATP sources in working muscle cont.

  25. WORKING MUSCLE FIBERS METABOLISM

  26. Aerobic Vs. Anaerobic sources of energy Aerobic Not require oxygen Source of energy: mainly fatty acids, then carbohydrate End Products: CO2, H2O & ATP • Anaerobic • Requires oxygen • Source of energy: • ONLY Carbohydrate (anaerobic glycolysis) • End Products: • Lactate & ATP

  27. The Cori cycle&The glucose-alanine cycle

  28. The Cori cycle Liver converts lactate into glucose via gluconeogenesis The newly formed glucose is transported to muscle to be used for energy again

  29. The glucose-alanine cycle Muscles produce: 1- Pyruvatefrom glycolysis during exercise 2- NH2produced from normal protein degradation Pyruvate + NH2 Alanine Alanineis transported through the blood to liver Liver converts alanine back to pyruvate Alanine – NH2 = Pyruvate Pyruvateis converted to glucose (gluconeogenesis). Glucose is transported to muscle to be used for energy again. Liver converts NH2 to urea for excretion (urea cycle)

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