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Loci’s frequency in HIV positive and uninfected individuals

Loci’s frequency in HIV positive and uninfected individuals. Cecilia Varnagy-Moskovitz. Loci’s frequency in HIV positive and uninfected individuals. Definitions: Loci: specific physical location of a gene on a chromosome.

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Loci’s frequency in HIV positive and uninfected individuals

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  1. Loci’s frequency in HIV positive and uninfected individuals Cecilia Varnagy-Moskovitz

  2. Loci’s frequency in HIV positive and uninfected individuals • Definitions: • Loci: specific physical location of a gene on a chromosome. • Chi-square test: method for testing the association between two variables in a two-way table (Chase) • G-test: similar to the Chi-square test but less sensitive to low expected values (Zar)

  3. Loci’s frequency in HIV positive and uninfected individuals • The graphic represents the different frequency of the loci tested. • Comparison between the two types of individuals tested. • “Significant departure from genotypic equilibrium” in the case of CKR5 (Dean et al).

  4. Loci’s frequency in HIV positive and uninfected individuals

  5. References • Chase et al. The Role of Sports as a Social Determinant for Children. 1992.February 2005. Source: http://www.stat.yale.edu/Courses/1997-98/101/chisq.htm • Dean et al. Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CKR5 Structural Gene. Science.273(5283): 1856-1862. 1996. February 2005.http://www.sciencemag.org/cgi/content/full/273/5283/1856/F2 • ESR. Glossary of Terms. 2000. February 2005. http://www.esr.cri.nz/features/esr_and_dna/media/glossary.html • Zar J.H. Biostatistical Analysis. 1984. February 2005.

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