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Lecture 13 – Project selection & Signalling Cross Talk

Lecture 13 – Project selection & Signalling Cross Talk. BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared by Bob Locy Last modified -13F. Module 7: Figure metabolic energy network.

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Lecture 13 – Project selection & Signalling Cross Talk

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  1. Lecture 13 – Project selection & Signalling Cross Talk BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared by Bob Locy Last modified -13F

  2. Module 7: Figure metabolic energy network Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  3. Module 7: Figure control of food intake Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  4. Module 7: Figure pancreas Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  5. Module 7: Figure β-cell signalling Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  6. Module 7: Figure α-cell signalling Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  7. Module 7: Figure liver cell signalling Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  8. CREB (Cyclic AMP response element-binding protein) • CREB (Cyclic AMP response element-binding protein)functions in the control of many different cellular processes: • The survival and proliferation of β-cells is regulated by glucose and by various hormones such as • glucagon-like peptide-1 (GLP-1) • Which appear to act synergistically to activate the CREB co-activators called TORCs • Regulating the biosynthesis of Glucagon • Activation of neuronal gene transcription responsible for learning and memory • Expression of clock genes • Expression of brain-derived neutrophic factor (BDNF) • Fast-spiking interneurons (Module 12: Figure schizophrenia). • The CREB/TORC transcriptional duo play a critical role in energy metabolism • peroxisome-proliferator-activated receptor γ (PPARγ) coactivator-1 (PGC-1) • PPAR transcription factors - function in liver cell gluconeogenesis • Transcriptional regulation aquaporin AQP2 and AQP3 - vasopressin-induced antidiuresis • Melanogenesis • NMDA receptor hypofunction in schizophrenia. Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  9. Module 7: Figurewite fat cells Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  10. Module 7:Figure lipolysis and lipogenesis Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  11. Module 7: Figure brown fat cells Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  12. Module 7: Figure liver cell signalling Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  13. Module 7: Figureglycogenolysis and gluconeogenesis Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  14. Module 7: Figure liver cell signalling Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

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