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Neurotrophin Signaling and Motor Neuron Survival

Explore the role of neurotrophins in promoting motor neuron survival and outgrowth of axons in target tissues, with a focus on Neuromuscular Junction and the effect of NGF on cell survival. Understand the differential effects of neurotrophins and the action of target-derived factors in supporting neuronal health.

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Neurotrophin Signaling and Motor Neuron Survival

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Presentation Transcript

  1. Motorneuron survival depends on the target

  2. Extra target tissue promotes motorneuron survival

  3. Effect of NGF on the outgrowth of axons

  4. NGF supports cell survival

  5. Differential effects of neurotrophins on axon outgrowth

  6. Action of target-derived neurotrophins

  7. Neurorotrophins and their receptors

  8. Neurotrophin Signaling

  9. The neuromuscular junction

  10. Role of Agrin in NMJ development

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