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Personalised medicine in Sweden. Mikael Benson, Centre for Personalised Medicine, Linköping University. Resources for Personalised Medicine (PM) in Sweden. Patient. Politicians. Clinicians. Ethics. Health C are. PM. Funders. Academia. National R esources. Industry.
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Personalised medicine in Sweden Mikael Benson, Centre for Personalised Medicine, Linköping University
Resources for Personalised Medicine (PM) in Sweden • Patient • Politicians • Clinicians • Ethics • Health Care • PM • Funders • Academia • National Resources • Industry • International Collaboration
Resources for Personalised Medicine (PM) in Sweden • Patients • Politicians • Clinicians • Ethics • Health Care • PM • Funders • Academia • National Resources • Industry • International Collaboration
Example from Multiple Sclerosis: Combinations of genetic, clinical and environmmental factors for PM Olsson T el al. Nature Rev Neurol (In press)
Patients • Politicians • Clinicians • Ethics • Health Care • PM • Funders • Academia • National Resources • Industry • International Collaboration
Need for proofofconcept studies Projects that show clinical feasibility of PM in specific diseases within 3-5 years Analyses of health economics
Patients • Politicians • Clinicians • Ethics • Health Care • PM • Funders • Academia • National Resources • Industry • International Collaboration
Ryhov County Hospital “Unselected” patients County Hospital conditions important for implementation • Futurum Academy for clinical research
Centre for PersonalisedMedicine (CPMed), Linköping • University Hospital • Medical faculty • Technicalfaculty • CPMed • Multi-disciplinary team: omics, bioinformatics, functional and clinical researchers • National and international collaborations • Industry
Regional investigationabout PM in East Gothia (Östergötland) • Are there diseases that are particularly suitable for implementation of PM within 3-5 years? • A health economics analysis for a regional effort towards PM
Resources for Personalised Medicine (PM) in Sweden • Patient • Politicians • Clinicians • Ethics • Health Care • PM • Funders • Academia • National Resources • Industry • International Collaboration
Industry Example from AstraZeneca
AstraZeneca 80 % of drug pipeline includes PM components Combining omics analyses of 2 million patients with clinical data to find subgroups and new targets Several collaborations with academia
Industry Diagnostics: biotech, biomarkers and software Health care industry
Big US companies are investing heavily in personalised medicine
Patients • Politicians • Clinicians • Ethics • Health Care • PM • Funders • Academia • National Resources • Industry • International Collaboration
National resources Population-wide registries Bioinformatics (BILS) • Biobanks (BBMRI) SciLife Lab National high performance computer
Funders Swedish Research Council Vinnova Swedish Foundation for Strategic Research Wallenberg Foundation
Example VR and Vinnovaarelaunching a National programme in protein research and biopharmaceuticaldrugs (320 millions SEK for 2016-2023)
Need for proofofconcept studies Projects that show clinical feasibility of PM in specific diseases within 3-5 years
Summary • PM already partially implemented in health care • All resources for general implementation are available in Sweden • Need for national coordination and dedicated funding for clinically oriented proof-of concept studies
Ideal • Equality in health care
Problem • Equality in health care ≠same care ?