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Inhaled Therapeutics using Dry Powder Inhalers (DPI)

Inhaled Therapeutics using Dry Powder Inhalers (DPI). Scott Selig ‘19 Biomedical Engineering. Intro: Common Lung Diseases which compromise Airflow. "Lung Diseases: Types and Causes of Common Conditions." WebMD . Ed. Varnada Karriem-Norwood. WebMD, 23 Mar. 2014. Web. 31 Oct. 2015.

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Inhaled Therapeutics using Dry Powder Inhalers (DPI)

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  1. Inhaled Therapeutics using Dry Powder Inhalers (DPI) Scott Selig ‘19 Biomedical Engineering

  2. Intro: Common Lung Diseases which compromise Airflow "Lung Diseases: Types and Causes of Common Conditions." WebMD. Ed. Varnada Karriem-Norwood. WebMD, 23 Mar. 2014. Web. 31 Oct. 2015.

  3. Intro: Problems with Medicating Targeted Area using an Inhaler Jat, Kana Ram, Kamal Kumar Singhal, and Vishal Guglani. "Autohaler versus Metered-dose Inhaler with Spacer in Children with Asthma." Pediatr Allergy Immunol Pediatric Allergy and Immunology (2015): n. pag. Pubmed. Web. 31 Oct. 2015.

  4. Intro: Advantages of Dry Powder Inhalers (DPIs) http://www.capsugel.com/ihc/dry-powder-inhaler-capsules Jat, Kana Ram, Kamal Kumar Singhal, and Vishal Guglani. "Autohaler versus Metered-dose Inhaler with Spacer in Children with Asthma." Pediatr Allergy Immunol Pediatric Allergy and Immunology (2015): n. pag. Pubmed. Web. 31 Oct. 2015.

  5. Method: Testing the Design of the Autohaler™ • Autohaler • multi-dose DPI • http://www.mikesouth.org.au/Asthma_devices/MDIs/album/slides/airomir%20autohaler.html http://www.wikihow.com/Use-an-Inhaler Jat, Kana Ram, Kamal Kumar Singhal, and Vishal Guglani. "Autohaler versus Metered-dose Inhaler with Spacer in Children with Asthma." Pediatr Allergy Immunol Pediatric Allergy and Immunology (2015): n. pag. Pubmed. Web. 31 Oct. 2015.

  6. Result: Testing the Design of the Autohaler™ Jat, Kana Ram, Kamal Kumar Singhal, and Vishal Guglani. "Autohaler versus Metered-dose Inhaler with Spacer in Children with Asthma." Pediatr Allergy Immunol Pediatric Allergy and Immunology (2015): n. pag. Pubmed. Web. 31 Oct. 2015.

  7. Three different blends of different grade lactose supplement with different levels of fine lactose were used • Using three different DPIs (Aeroliser, Handihaler, and Rotahaler), the different grades of lactose blends were tested for their in vitro particle distribution and drug deposition Method: Testing different blends of Lactose Coarse Carrier Particles with varying levels of Fine Lactose Muddle, Joanna, Darragh Murnane, Irene Parisini, Marc Brown, Clive Page, and Ben Forbes. "Interaction of Formulation and Device Factors Determine the In Vitro Performance of Salbutamol Sulphate Dry Powders for Inhalation." Journal of Pharmaceutical Sciences J. Pharm.

  8. Method: Testing different blends of Lactose Coarse Carrier Particles with varying levels of Fine Lactose Muddle, Joanna, Darragh Murnane, Irene Parisini, Marc Brown, Clive Page, and Ben Forbes. "Interaction of Formulation and Device Factors Determine the In Vitro Performance of Salbutamol Sulphate Dry Powders for Inhalation." Journal of Pharmaceutical Sciences J. Pharm.

  9. Method: Testing different Dry Powder Formulations Sympatec laser diffraction to determine particle size and shape www.sympatec.com Muddle, Joanna, Darragh Murnane, Irene Parisini, Marc Brown, Clive Page, and Ben Forbes. "Interaction of Formulation and Device Factors Determine the In Vitro Performance of Salbutamol Sulphate Dry Powders for Inhalation." Journal of Pharmaceutical Sciences J. Pharm.

  10. Results: Testing different Dry Powder Formulations (a) LH200 (b) ML001 (c) ML006 (white) Aeroliser (black) Handihaler (stripes) Rotahaler Jat, Kana Ram, Kamal Kumar Singhal, and Vishal Guglani. "Autohaler versus Metered-dose Inhaler with Spacer in Children with Asthma." Pediatr Allergy Immunol Pediatric Allergy and Immunology (2015): n. pag. Pubmed. Web. 31 Oct. 2015.

  11. Result: Testing different Dry Powder Formulations Jat, Kana Ram, Kamal Kumar Singhal, and Vishal Guglani. "Autohaler versus Metered-dose Inhaler with Spacer in Children with Asthma." Pediatr Allergy Immunol Pediatric Allergy and Immunology (2015): n. pag. Pubmed. Web. 31 Oct. 2015.

  12. Discussion: Pulmatrix iSperse™ http://bionews-tx.com/news/2014/05/14/pulmatrix-cystic-fibrosis-isperse-antibiotics/ Lipp, Michael M., and Jean C. Sung. Respirably Dry Powder Comprising Calcium Lactate, Sodium Chloride and Leucine. Patent 8,992,983. 31 Mar. 2015. Print.

  13. Any questions? [1] "Lung Diseases: Types and Causes of Common Conditions." WebMD. Ed. Varnada Karriem-Norwood. WebMD, 23 Mar. 2014. Web. 31 Oct. 2015. [2] Jat, Kana Ram, Kamal Kumar Singhal, and Vishal Guglani. "Autohaler versus Metered-dose Inhaler with Spacer in Children with Asthma." Pediatr Allergy Immunol Pediatric Allergy and Immunology (2015): n. pag. Pubmed. Web. 31 Oct. 2015. [3] Muddle, Joanna, Darragh Murnane, Irene Parisini, Marc Brown, Clive Page, and Ben Forbes. "Interaction of Formulation and Device Factors Determine the In Vitro Performance of Salbutamol Sulphate Dry Powders for Inhalation." Journal of Pharmaceutical Sciences J. Pharm. Sci. 104.11 (2015): 3861-869. Pubmed. Web. 31 Oct. 2015. [4] Holz, Olaf, H. Biller, M. Mueller, K. Kane, M. Rosano, J. Hanrahan, D. L. Hava, and J. M. Hohlfeld. "Efficacy and Safety of Inhaled Calcium Lactate PUR118 in the Ozone Challenge Model - a Clinical Trial." BMC Pharmacology and Toxicology BMC Pharmacol Toxicol 16.1 (2015): n. pag. Web. 31 Oct. 2015. [5] Lipp, Michael M., and Jean C. Sung. Respirably Dry Powder Comprising Calcium Lactate, Sodium Chloride and Leucine. Patent 8,992,983. 31 Mar. 2015. Print.

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