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Gross Unknowns

Gross Unknowns. Audrea Williams, MD Department of Pathology Howard University Hospital. A. Mammograms of young women are typically "dense" or white in appearance; difficult to detect lesions

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Gross Unknowns

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  1. Gross Unknowns Audrea Williams, MD Department of Pathology Howard University Hospital

  2. A. Mammograms of young women are typically "dense" or white in appearance; difficult to detect lesions B. Young woman's breast: predominance of fibrous interlobular stroma and the paucity of adipose tissue C. Pregnancy, branching of terminal ducts results in more numerous TDLUs, and the number of acini per TDLU increases. D. Increasing age: TDLUs decrease in size and number, and the interlobular stroma is replaced by adipose tissue E. Mammograms become more radiolucent (darker) with age secondary to small ducts and atrophic lobules in adipose tissue. Robbins and Cotran p.1120

  3. Robbins and Cotran p.1120

  4. Multiple masses in the breast of a 40-year-old woman. Excision was performed, what is the best diagnosis? A. Fibrocystic changes B. Ductal carcinoma in situ with apocrine change C. Apocrine carcinoma E. None of the above

  5. Multiple masses in the breast of a 40-year-old female. Excision was performed, what is the best diagnosis? A. Fibrocystic changes B. Ductal carcinoma in situ with apocrine change C. Apocrine carcinoma E. None of the above

  6. Multiple masses in the breast of a 40-year-old female. Excision was performed, what is the best diagnosis? A. Fibrocystic changes B. Ductal carcinoma in situ with apocrine change C. Apocrine carcinoma E. None of the above Fibrocystic changes

  7. 64F bilateral skin/breast changes secondary to implants

  8. Left breast: lobular carcinoma insitu (E-cadherin negative)

  9. Rigt breast : Invasive moderately differentiated ductal carcinoma

  10. Uterus is hollow, pear shaped, 40-80 g, 7-8 cm Histology of the menstrual cycle early proliferative (days 4-7) days 20-21: maximal secretion post-ovulatory day 2 Robbins and Cotran p.1120

  11. 24 year old woman with polycystic ovarian syndrome (prolonged estrogenic stimulation with reduced progestational activity) and abnormal uterine bleeding Endometrial hyperplasia

  12. 47 year old woman with abnormal uterine bleeding DDx: Endometrial Carcinoma Endometrial polyps Leiomyomas(Fibroids)

  13. 47 year old woman with abnormal uterine bleeding DDx: Endometrial Carcinoma Endometrial polyps Leiomyomas(Fibroids)

  14. 47 year old woman with abnormal uterine bleeding DDx: Endometrial Carcinoma Endometrial polyps Leiomyomas(Fibroids)

  15. Robbins and Cotran p.1094

  16. 27 year old woman with severe abdominal pain; this is the ovary Hint: endometrial glands and stroma outside the uterus Endometriosis of Ovary Dx 2 of 3 are required: endometrial glands, stroma hemosiderin-laden macrophages

  17. 27 year old woman with severe abdominal pain this is the ovary Hint: endometrial glands and stroma outside the uterus Endometriosis of Ovary Dx: 2 of 3 are required: endometrial glands, stroma hemosiderin-laden macrophages

  18. 29 year old woman with a cystic ovarian mass benign serous cystadenoma

  19. 49 year old woman with a cystic ovarian mass Papillary serous cystadenocarcinoma

  20. 30 cm retroperitoneal cystic mass in 55 year old woman mucinous cystadenoma fluid to viscous material of mucoid nature in lumen

  21. mucinous ovarian neoplasm that had borderline features at the microscopic level

  22. mucinous cystadenocarcinoma

  23. 65 year old lady with stage IV malignancy uterus700grams

  24. A07-25

  25. epithelial component

  26. necrosis

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