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120. 140. 120. 100. 100. 80. Relative FITC Signal (%). Relative FITC Signal (%). 80. 60. 60. 40. 40. 20. 20. 0. 0. 0. 20. 40. 60. 80. 100. 120. 0. 100. 200. 300. 400. Time (min). TUDCA ( m M). A. B. Supplemental Fig. 1. Kim et al. TUDCA. TUDCA. (min). (min). 0.

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  1. 120 140 120 100 100 80 Relative FITC Signal (%) Relative FITC Signal (%) 80 60 60 40 40 20 20 0 0 0 20 40 60 80 100 120 0 100 200 300 400 Time (min) TUDCA (mM) A. B. Supplemental Fig. 1. Kim et al.

  2. TUDCA TUDCA (min) (min) 0 15 30 60 0 15 30 60 PKCa PKCa PKCd PKCd Hsp90 EGFR Cytoplasm Membrane TUDCA - TUDCA - + + + + - - BAPTA - - BAPTA + + PKCa PKCa PKCd PKCd EGFR Hsp90 Membrane Cytoplasm A. B. Supplemental Fig. 2. Kim et al.

  3. 1.7 120 * * 1.5 100 1.3 80 1.1 Relative BrDU Incorporation rate(%) Cell Number(X106) 60 0.9 40 0.7 20 0.5 0 0 50 100 200 0 50 100 200 TUDCA (mM) TUDCA (mM) A. B. Control TUDCA 50mM TUDCA 100mM TUDCA 200mM 50mm C. Supplemental Fig. 3. Kim et al.

  4. * * 120 100 80 VSMC migration(%) 60 40 20 0 0 50 100 200 TUDCA (mM) * * 120 100 80 VSMC migration(%) 60 40 20 0 - Con H7 TUDCA A. B. MMP-9 MMP-9 WB WB Tubulin Tubulin Zymography Zymography ProMMP-9 ProMMP-9 MMP-9 MMP-9 MMP-9 Tubulin * * VSMC migration(%) C. Con Con MMP-9 MMP-9 Si- - TUDCA + Zymography ProMMP-9 MMP-9 Supplemental Fig. 4. Kim et al.

  5. Mean Medial Cells/sections Relative Medial Area (%) 500 120 100 400 80 300 60 Con 10 50 100 Con 10 50 100 TUDCA(mg/kg) 200 TUDCA(mg/kg) 40 100 20 0 0 A. B. Supplemental Fig. 5. Kim et al.

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