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The road to DNA, its importance and structure

The road to DNA, its importance and structure. Griffith, Avery, Macleod 1944. Transformation: DNA could transform cells whereas proteins could not. Chargaff: 1947. Equal % of C and G Equal % of A and T. Hershey and Chase: 1952. Franklin’s X-ray crystallography: early 1950’s.

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The road to DNA, its importance and structure

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  1. The road to DNA, its importance and structure

  2. Griffith, Avery, Macleod 1944 • Transformation: DNA could transform cells whereas proteins could not

  3. Chargaff: 1947 • Equal % of C and G • Equal % of A and T

  4. Hershey and Chase: 1952

  5. Franklin’s X-ray crystallography: early 1950’s Had to be able to crystalize molecule Regular pattern= helix

  6. Waston and crick: 1953 • Double helix model

  7. Messelson and Stahl: late 1950’s: Semi-conservative replication

  8. Chromosome structure: later

  9. DNA structure • Antiparallel: opposite directions

  10. Complementary: base pairs • Always one purine (double ring) A or G • Always one pyrimidine (single ring) C or T • A/T only has two H bonds so it is easier to unzip.

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