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Characterization of L3MBTL2 MBT Binding with Histone Peptides

L3MBTL2, MBT binding, histone peptides, H3K4me1, H3K9me1, H3K27me1, H3K9me2, H3K27me2, thermodynamic parameters, monomethylated Lysine

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Characterization of L3MBTL2 MBT Binding with Histone Peptides

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  1. ITC characterization of L3MBTL2 4MBT binding with different histone peptides H3K4me1 H3K9me1 H3K27me1 H3K9me2 H3K27me2 KD = 23 µM KD = 43 µM KD = 56 µM KD = 9 µM KD = 38 µM Supplementary Figure 3a

  2. Monomethylated Lysine interaction with L3MBTL2 The binding of monomethylated lysine to L3MBTl2 is very weak (~4000 uM) Supplementary Figure 3b

  3. Thermodynamic parameters of the interaction of L3MBTL2 with histone peptides Supplementary Figure 3c

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