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CoQ Clear

Coenzyme Q10. . COENZYME Q10CoQ10 exists in distinct 2 forms: Oxidized (ubiquinone) Reduced (ubiquinol, QH2) It is the oxidized form that is manufactured and sold as what we know as CoQ10, primarily because the reduced form is not a very stable form especially for storage. The body

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CoQ Clear

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    1. CoQ Clear

    10. Cis- verses trans-isomers Trans isomer Inflexible stiff bonds Cis isomers Flexible bonds

    16. Accumulated Area Under the Curve [AUC (0-28 day)] for the CoQ Clear CF and Q-Dry Powder products. Note the significantly (p< 0.001) greater (441%) for the CoQ Clear CF compared to the Q-Dry Powder produuct. Accumulated Area Under the Curve [AUC (0-28 day)] for the CoQ Clear CF and Q-Dry Powder products. Note the significantly (p< 0.001) greater (441%) for the CoQ Clear CF compared to the Q-Dry Powder produuct.

    17. CoQ10 Absorption Absorption: The amount of a single known ingested dose of CoQ10 transported from the small intestines into the blood plasma. It involves several phases: ingestion by mouth, dissolution (the breakdown of single CoQ10 crystals into single molecules) in the stomach and small intestine into the absorption cells which deliver CoQ10 into the lymphatics, and then into the general circulation of the blood, where CoQ10 becomes bioavailable. Without absorption in the small intestine, CoQ10 is literally flushed out of the body and is not available to the body; without absorption, CoQ10 cannot be bioavailable. Measured by the time base changes in the amount of CoQ10 appearing in the blood plasma after the ingestion of a single known dose of CoQ10. (Measured during the intestinal absorption interval)

    18. CoQ10 Absorption Process Facilitated passive diffusion Lipid transport and carrier system Slow and poor absorption process Dual transport from intestines to the cells a. Lympathetic system (Lipid carrier) b. Circulatory system (Lipid carrier [LDL]) Slow turnover rate (3.5 mg/day Sedentary and 6.5 mg/day Athletes and some clinical conditions) Point out that it must go thru the lymphatics and the more exercise Will increase CoQ10 levelsPoint out that it must go thru the lymphatics and the more exercise Will increase CoQ10 levels

    19. CoQ10 Micrographs

    20. Absorption Study Randomized double-blind study design Heterogeneous normal M/F group N=20. Single oral dose (100mg) Fasted and basal condition Serial blood samples over 36 hours Breakfast containing lipid but no CoQ10 to activate intestines. No food until after 6 hours. The study, remember this is 10 people on each side of the study But these studies have been duplicated 3 more times. That is significant.The study, remember this is 10 people on each side of the study But these studies have been duplicated 3 more times. That is significant.

    21. Formulation of Physiologically Formulated Lipid Solvent: Crystals dissolved to single CoQ10 molecules (The body cant absorb a crystal) Lipid Stabilizer: Prevent recrystallization at room temperatures Lipid Carrier: Passive facilitated diffusion absorption process Great opportunity to talk about the whole process Of how it is made.Great opportunity to talk about the whole process Of how it is made.

    22. Absorption Study No one will be able to compare at 100 mg of CoQ Clear CF At 8 hours with no fatty meals and no CoQ10 taken in the meals. 3.2 is the mark everyone will try to reach.No one will be able to compare at 100 mg of CoQ Clear CF At 8 hours with no fatty meals and no CoQ10 taken in the meals. 3.2 is the mark everyone will try to reach.

    23. CoQ Clear CF Bioavailability Plasma CoQ10 bioavailability for CoQ Clear CF and Q-Dry Powder. Note the significantly (p< 0.001) greater (265 %) plasma CoQ10 for the Q-Best compared to the Q-Dry powder product Plasma CoQ10 bioavailability for CoQ Clear CF and Q-Dry Powder. Note the significantly (p< 0.001) greater (265 %) plasma CoQ10 for the Q-Best compared to the Q-Dry powder product

    24. CoQ Clear CF Bioavailability Total micrograms in plasma which might be a better way of Evaluating CoQ10 levels in the future. Do to body size, and weight.Total micrograms in plasma which might be a better way of Evaluating CoQ10 levels in the future. Do to body size, and weight.

    25. Bioavailability Kinetics Please compare Cmaxs and total blood (ug/ml Day)Please compare Cmaxs and total blood (ug/ml Day)

    26. Absorption Study Single dose (100mg) CoQ10 absorption profiles for CoQ Clear CF and Q-Dry Powder. Note the significantly(p< 0.0001) greater Plasma CoQ10 at Cmax for the CoQ Clear CF product. Single dose (100mg) CoQ10 absorption profiles for CoQ Clear CF and Q-Dry Powder. Note the significantly(p< 0.0001) greater Plasma CoQ10 at Cmax for the CoQ Clear CF product.

    27. Absorption Comparisons (% of Dose at Cmax) Percent absorption of different CoQ10 product types at Cmax. Note the significntly (p<0.001) greater absorption of the CoQ Clear CF product and the percentage of the CoQ Clear CF above the other product types.Percent absorption of different CoQ10 product types at Cmax. Note the significntly (p<0.001) greater absorption of the CoQ Clear CF product and the percentage of the CoQ Clear CF above the other product types.

    30. NovaSol Nano Particle Study Please be make sure your doctor knows that if someone says the nano is 75% absorbed 100mg at 75% = 75 mg in the blood stream 3600 ml of blood would give them about a 27 ug/ml not possible Please be make sure your doctor knows that if someone says the nano is 75% absorbed 100mg at 75% = 75 mg in the blood stream 3600 ml of blood would give them about a 27 ug/ml not possible

    31. Bio-equivalent Doses Co Qmax CF Dry Powder Micelle Nano Particle 30 mg 200 100 90 50 mg 500 160 140 70 mg 650 200 175 80 mg 750 250 200 90 mg 800 275 240 100 mg 950 300 260

    34. Numedica delivers in Price 30 softgel Dr. Cost; 10.75 Retail Cost: 21.50 120 softgel Dr. Cost; 34.95 Retail Cost: 58.95

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