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L692P

Supplementary I to Figure 1A. Ex18. Ex 19. Ex18. Ex 19. del745-9. del745-9. del746-50DP. del746-51VP. del746-53VS. del747-50P. del746-50DP. del746-51VP. del746-53VS. del747-50P. del746-50IP. del752-9. del747-53Q. del747-51Q. del746-50IP. del752-9. del746-52D. del746-51A.

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L692P

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  1. Supplementary I to Figure 1A Ex18 Ex 19 Ex18 Ex 19 del745-9 del745-9 del746-50DP del746-51VP del746-53VS del747-50P del746-50DP del746-51VP del746-53VS del747-50P del746-50IP del752-9 del747-53Q del747-51Q del746-50IP del752-9 del746-52D del746-51A del747-51P del746-52V del747-51Q del747-53Q del747-53S del746-52D del746-51A del746-52V del747-51P del747-53S del747-52 del746-50 del746-51 del746-52 del747-49 del747-50 del747-53 del747-51 del747-52 del746-51 del747-53 del746-50 del746-52 del747-49 del747-50 del747-51 G724S G719A E709G G719C G719A G724S E709K E709G G719C E709A L692P E709K E709A L692P ------ ------ wt mt A. C. 100,000 wt (300 ng genomic DNA) + 100,000 mt (50%) 100,000 wt(300 ng genomic DNA) + 125 mt (0.125%) Ex18 Ex 19 Ex18 Ex 19 del745-9 del745-9 del746-50DP del746-51VP del746-53VS del746-50DP del747-50P del746-51VP del746-53VS del747-50P del746-50IP del752-9 del746-50IP del752-9 del747-53Q del747-51Q del746-52D del746-51A del747-51Q del747-53Q del746-52V del747-51P del746-52D del746-51A del747-53S del746-52V del747-51P del747-53S del747-52 del747-50 del747-53 del746-50 del746-51 del746-52 del747-49 del747-52 del747-51 del747-53 del746-50 del746-51 del746-52 del747-49 del747-50 del747-51 G719A G724S E709G G719C G719A G724S E709G G719C E709K E709A E709K L692P E709A L692P ------ ------ wt mt B. D. 100,000 wt ( 300 ng genomic DNA) + 5000 mt (5%) 100,000 wt (300 ng genomic DNA) + 62.5 mt (0.063%)

  2. Supplementary II to Figure 1A Ex 19 RM Ex 19 RM del745-9 del745-9 del746-50DP del746-51VP del746-53VS del746-50DP del747-50P del746-51VP del746-53VS del747-50P ins770NPG del752-9 ins770SVQ del747-53Q insN771GT del747-51Q del746-50IP del747-53S ins770NPG del746-52D del752-9 ins770SVQ del746-51A insN771GT del747-53Q del746-52V del747-51Q del746-50IP del747-51P del746-52D del747-53S del746-51A del746-52V del747-51P del746-52 del746-50 del747-49 del747-51 del746-51 del747-53 del747-52 del746-52 del747-50 del746-50 del747-49 del747-51 del746-51 del747-53 del747-52 del747-50 T790M D761Y T790M V769L D761Y V769L S768l S768l ------ ------ wt mt A. C. 100,000 wt (300 ng genomic DNA) + 100,000 mt (50%) 100,000 wt(300 ng genomic DNA) + 625 mt (0.625%) Ex 19 RM Ex 19 RM del745-9 del745-9 del746-50DP del746-51VP del746-50DP del746-53VS del746-51VP del747-50P del746-53VS del747-50P ins770NPG del752-9 ins770SVQ insN771GT del747-53Q del747-51Q del746-50IP ins770NPG del752-9 del747-53S del746-52D ins770SVQ del747-53Q insN771GT del746-51A del747-51Q del746-52V del746-50IP del746-52D del747-53S del747-51P del746-51A del746-52V del747-51P del746-52 del746-50 del747-49 del747-52 del747-52 del746-51 del747-53 del747-51 del746-52 del746-50 del747-49 del747-50 del746-51 del747-53 del747-51 del747-50 T790M D761Y T790M D761Y V769L V769L S768l S768l ------ ------ wt mt B. D. 100,000 wt ( 300 ng genomic DNA) + 5000 mt (5%) 100,000 wt(300 ng genomic DNA) + 312.5 mt (0.313%)

  3. Supplementary to Figure 1B Ex20 Ex21 Ex20 Ex20 Ex21 Ex20 ins761EAFQ ins761EAFQ insN771GF ins773NPH ins770SVD ins772PR1 ins772PR2 insN771GF ins773NPH ins770SVD ins772PR2 ins772PR1 ins769GV ins769GS ins773VH ins769AS ins769GS ins769GV ins773VH ins769AS V765M Q787R V769M V774M G779S R776H H773R S768C K846R L858M G779F L861Q K806E V765M V774M V769M Q787R L798H H835L A839T L858R L861R G779S H773R R776H L814P L838V V834L S768C G779F K846R L858M L861Q K806E L798H H835L L858R A839T L861R L833V L814P L833V V834L L838V ------ ------ wt mt A. 10,000 wt (30ng genomic DNA) + 10,000 mt wt mt B. 10,000 wt (30ng genomic DNA) + 10 mt

  4. Supplementary Figure 3a Ex20 Ex20 Ex20 Ex20 Ex21 Ex21 Ex20 Ex20 Ex18 Ex 19 RM ins761EAFQ ins761EAFQ ins770NPG ins770NPG ins770SVQ ins770SVQ insN771GF ins773NPH insN771GT ins773NPH insN771GT insN771GF ins770SVD ins770SVD ins772PR1 ins772PR2 ins772PR2 ins772PR1 ins769GS ins769GV ins769GS ins769GV ins773VH ins773VH ins769AS ins769AS T 790M T 790M T 790M T 790M V765M V769M V774M Q787R V765M V769M V774M Q787R G779S G779S H773R R776H H773R R776H S768C G779F K846R L858M S768C G779F K846R L858M K806E L861Q K806E L861Q L798H H835L A839T L858R L861R L798H L858R H835L A839T L861R L814P L833V V834L L838V V769L L814P V769L L833V V834L L838V S768I S768I ------ ------ del745-9 del746-51VP del746-53VS del746-50DP del747-50P del746-50IP ins770NPG del752-9 ins770SVQ insN771GT del747-53S del747-53Q del747-51Q del746-52D del747-51 del746-52V del747-51P del746-51A del746-50 del747-53 del746-51 del747-50 del747-52 del747-49 del746-52 G719C T790M G724S E709G G719A D761Y E709A E709K V769L L692P S768l ------ ------ MC 005 F/81 MC 005 F/81 Ex18 Ex 19 RM del745-9 del746-51VP del746-53VS del746-50DP del747-50P del746-50IP del752-9 ins770NPG ins770SVQ insN771GT del747-53S del747-51Q del747-53Q del746-52D del747-51 del746-52V del747-51P del746-51A del746-50 del746-51 del747-50 del747-53 del747-49 del747-52 del746-52 G719C T790M G724S E709G G719A D761Y E709A E709K V769L L692P S768l ------ ------ MC 007 M/53 MC 007 M/53

  5. Supplementary Figure 3b Ex20 Ex20 Ex20 Ex20 Ex21 Ex21 Ex20 Ex20 Ex18 Ex 19 RM ins761EAFQ ins761EAFQ ins770NPG ins770NPG ins770SVQ ins770SVQ insN771GF ins773NPH insN771GT ins773NPH insN771GT insN771GF ins770SVD ins770SVD ins772PR1 ins772PR2 ins772PR1 ins772PR2 ins769GS ins769GV ins769GS ins769GV ins773VH ins773VH ins769AS ins769AS T 790M T 790M T 790M T 790M V765M V769M V774M Q787R V765M V769M V774M Q787R G779S G779S H773R R776H H773R R776H S768C G779F K846R L858M S768C G779F K846R L858M K806E L861Q K806E L861Q L798H H835L A839T L858R L861R L798H L858R H835L A839T L861R L814P L833V V834L L838V V769L V769L L814P L833V V834L L838V S768I S768I ------ ------ del745-9 del746-51VP del746-53VS del746-50DP del747-50P del746-50IP ins770NPG del752-9 ins770SVQ insN771GT del747-53S del747-53Q del747-51Q del746-52D del747-51 del746-52V del747-51P del746-51A del746-50 del747-53 del746-51 del747-50 del747-52 del747-49 del746-52 G719C T790M G724S E709G G719A D761Y E709A E709K V769L L692P S768l ------ ------ Ex18 Ex 19 RM del745-9 del746-51VP del746-53VS del746-50DP del747-50P del746-50IP del752-9 ins770NPG ins770SVQ insN771GT del747-53S del747-51Q del747-53Q del746-52D del747-51 del746-52V del747-51P del746-51A del746-50 del746-51 del747-50 del747-53 del747-49 del747-52 del746-52 G719C T790M G724S E709G G719A D761Y E709A E709K V769L L692P S768l ------ ------

  6. Supplementary Figure 3c Ex20 Ex20 Ex20 Ex20 Ex21 Ex21 Ex20 Ex20 Ex18 Ex 19 RM ins761EAFQ ins761EAFQ ins770NPG ins770NPG ins770SVQ ins770SVQ insN771GF ins773NPH insN771GT ins773NPH insN771GT insN771GF ins770SVD ins770SVD ins772PR1 ins772PR2 ins772PR1 ins772PR2 ins769GS ins769GV ins769GS ins769GV ins773VH ins773VH ins769AS ins769AS T 790M T 790M T 790M T 790M V765M V769M V774M Q787R V765M V769M V774M Q787R G779S G779S H773R R776H H773R R776H S768C G779F K846R L858M S768C G779F K846R L858M K806E L861Q K806E L861Q L798H H835L A839T L858R L861R L798H L858R H835L A839T L861R L814P L833V V834L L838V V769L V769L L814P L833V V834L L838V S768I S768I ------ ------ del745-9 del746-51VP del746-53VS del746-50DP del747-50P del746-50IP ins770NPG del752-9 ins770SVQ insN771GT del747-53S del747-53Q del747-51Q del746-52D del747-51 del746-52V del747-51P del746-51A del746-50 del747-53 del746-51 del747-50 del747-52 del747-49 del746-52 G719C T790M G724S E709G G719A D761Y E709A E709K V769L L692P S768l ------ ------ MC 010 M/74 MC 010 M/74 Ex18 Ex 19 RM del745-9 del746-51VP del746-53VS del746-50DP del747-50P del746-50IP del752-9 ins770NPG ins770SVQ insN771GT del747-53S del747-51Q del747-53Q del746-52D del747-51 del746-52V del747-51P del746-51A del746-50 del746-51 del747-50 del747-53 del747-49 del747-52 del746-52 G719C T790M G724S E709G G719A D761Y E709A E709K V769L L692P S768l ------ ------ MC 004 F/57 MC 004 F/57

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